Document Detail

Dietary Contaminant Exposure Affects Plasma Testosterone, but not Thyroid Hormones, Vitamin A, and Vitamin E, in Male Juvenile Arctic Foxes (Vulpes lagopus).
MedLine Citation:
PMID:  23030655     Owner:  NLM     Status:  In-Data-Review    
Levels of persistent organic pollutants (POP), such as polychlorinated biphenyls (PCB), are high in many Arctic top predators, including the Arctic fox (Vulpes lagopus). The aim of this study was to examine possible endocrine-disruptive effects of dietary POP exposure in male juvenile Arctic foxes in a controlled exposure experiment. The study was conducted using domesticated farmed blue foxes (Vulpes lagopus) as a model species. Two groups of newly weaned male foxes received a diet supplemented with either minke whale (Baleneoptera acutorostrata) blubber that was naturally contaminated with POP (exposed group, n = 5 or 21), or pork (Sus scrofa) fat (control group, n = 5 or 21). When the foxes were 6 mo old and had received the 2 diets for approximately 4 mo (147 d), effects of the dietary exposure to POP on plasma concentrations of testosterone (T), thyroid hormones (TH), thyroid-stimulating hormone (TSH), retinol (vitamin A), and tocopherol (viramin E) were examined. At sampling, the total body concentrations of 104 PCB congeners were 0.1 ± 0.03 μg/g lipid weight (l.w.; n = 5 [mean ± standard deviation]) and 1.5 ± 0.17 μg/g l.w. (n = 5) in the control and exposed groups, respectively. Plasma testosterone concentrations in the exposed male foxes were significantly lower than in the control males, being approximately 25% of that in the exposed foxes. There were no between-treatment differences for TH, TSH, retinol, or tocopherol. The results suggest that the high POP levels experienced by costal populations of Arctic foxes, such as in Svalbard and Iceland, may result in delayed masculine maturation during adolescence. Sex hormone disruption during puberty may thus have lifetime consequences on all aspects of reproductive function in adult male foxes.
Ingeborg G Hallanger; Even H Jørgensen; Eva Fuglei; Oystein Ahlstrøm; Derek C G Muir; Bjørn Munro Jenssen
Related Documents :
23347605 - Role of phyto-oestrogens in ovulation induction in women with polycystic ovarian syndrome.
24197445 - Overripening of ovulated eggs in goldfish, carassius auratus: ii. possible involvement ...
24094635 - Principles and pitfalls of free hormone measurements.
23313605 - Blunted salivary and plasma cortisol response in patients with panic disorder under psy...
3004915 - Ontogeny of the stress response in the rat: role of the pituitary and the hypothalamus.
12856765 - Effects of hypothyroidism and withholding of feed on plasma lipid concentrations, conce...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  75     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  1298-313     Citation Subset:  IM    
a Department of Biology , University of Science and Technology , Trondheim , Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Screening-level risk assessment for styrene-acrylonitrile (SAN) trimer detected in soil and groundwa...
Next Document:  Is maximal lactate steady state during intermittent cycling different for active compared with passi...