Document Detail

Dietary B vitamin intakes and urinary total arsenic concentration in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort, Bangladesh.
MedLine Citation:
PMID:  20386915     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objective of this analysis was to evaluate the effects of dietary B vitamin intakes on creatinine-adjusted urinary total arsenic concentration among individuals participating in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Araihazar, Bangladesh. Arsenic exposure is a major public health problem in Bangladesh, where nearly 77 million people have been chronically exposed to arsenic through the consumption of naturally contaminated groundwater. Dietary factors influencing the metabolism of ingested arsenic may potentially be important modifiers of the health effects of arsenic in this population.
METHODS: Daily average B vitamin intakes from a validated food frequency questionnaire and laboratory data on drinking water and urinary arsenic concentrations among 9,833 HEALS cohort participants were utilized. Statistical analyses were conducted using generalized estimating equations incorporating knotted spline linear regression.
RESULTS: Increasing dietary intakes of thiamin, niacin, pantothenic acid, and pyridoxine were found to significantly increase urinary total arsenic excretion, adjusted for daily arsenic intake from drinking water and other potential confounders.
CONCLUSIONS: These results suggest that higher intakes of certain B vitamins may enhance the excretion of arsenic from the body. This study offers new insights into modifiable dietary factors that relate to arsenic excretion and thus provides potential avenues for the prevention of arsenic-related health effects.
Maria Argos; Paul J Rathouz; Brandon L Pierce; Tara Kalra; Faruque Parvez; Vesna Slavkovich; Alauddin Ahmed; Yu Chen; Habibul Ahsan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-04-13
Journal Detail:
Title:  European journal of nutrition     Volume:  49     ISSN:  1436-6215     ISO Abbreviation:  Eur J Nutr     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-01     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  473-81     Citation Subset:  IM    
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MeSH Terms
Arsenic / urine*
Cohort Studies
Cross-Sectional Studies
Diet / statistics & numerical data*
Environmental Exposure / analysis
Longitudinal Studies
Middle Aged
Protective Agents / administration & dosage
Sex Factors
Socioeconomic Factors
Vitamin B Complex / administration & dosage*
Water Pollutants, Chemical / urine*
Young Adult
Grant Support
P42ES010349/ES/NIEHS NIH HHS; R01 CA102484/CA/NCI NIH HHS; R01 CA102484-03/CA/NCI NIH HHS; R01 CA107431/CA/NCI NIH HHS; R01 CA107431-03/CA/NCI NIH HHS; R01CA102484/CA/NCI NIH HHS; R01CA107431/CA/NCI NIH HHS
Reg. No./Substance:
0/Protective Agents; 0/Water Pollutants, Chemical; 12001-76-2/Vitamin B Complex; N712M78A8G/Arsenic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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