Document Detail


Dietary antioxidants and forced expiratory volume in 1 s decline: the Health, Aging and Body Composition study.
MedLine Citation:
PMID:  22005919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased antioxidant defences are hypothesised to decrease age- and smoking-related decline in lung function. The relationship between dietary antioxidants, smoking and forced expiratory volume in 1 s (FEV(1)) was investigated in community-dwelling older adults in the Health, Aging and Body Composition study. 1,443 participants completed a food frequency questionnaire, self-reported smoking history and had measurements taken of FEV(1) at both baseline and after 4 yrs of follow-up. The association of dietary intake of nutrients and foods with antioxidant properties and rate of FEV(1) decline was investigated using hierarchical linear regression models. In continuing smokers (current smokers at both time-points), higher vitamin C intake and higher intake of fruit and vegetables were associated with an 18 and 24 mL · yr(-1) slower rate of FEV(1) decline compared with a lower intake (p < 0.0001 and p = 0.003, respectively). In quitters (a current smoker at study baseline who had quit during follow-up), higher intake was associated with an attenuated rate of decline for each nutrient studied (p ≤ 0.003 for all models). In nonsmoking participants, there was little or no association of diet and rate of decline in FEV(1). The intake of nutrients with antioxidant properties may modulate lung function decline in older adults exposed to cigarette smoke.
Authors:
A R Bentley; S B Kritchevsky; T B Harris; P Holvoet; R L Jensen; A B Newman; J S Lee; S Yende; D Bauer; P A Cassano;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-10-17
Journal Detail:
Title:  The European respiratory journal     Volume:  39     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-08-07     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  979-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / physiology*
Antioxidants / administration & dosage*
Body Composition*
Cohort Studies
Female
Follow-Up Studies
Food Habits
Forced Expiratory Volume*
Humans
Longitudinal Studies
Lung Diseases / diagnosis,  epidemiology*,  metabolism
Male
Oxidants / administration & dosage
Predictive Value of Tests
Respiratory Function Tests
Smoking / epidemiology*,  metabolism
Grant Support
ID/Acronym/Agency:
K24 AR051895/AR/NIAMS NIH HHS; N01 AG062101/AG/NIA NIH HHS; N01 AG062106/AG/NIA NIH HHS; N01-AG-2103/AG/NIA NIH HHS; N01-AG-6-2101/AG/NIA NIH HHS; N01-AG-6-2106/AG/NIA NIH HHS; R01 HL071022/HL/NHLBI NIH HHS; R01 HL074104/HL/NHLBI NIH HHS; R01HL071022/HL/NHLBI NIH HHS; R01HL74104/HL/NHLBI NIH HHS; T32 DK007158/DK/NIDDK NIH HHS; T32 DK007158-31/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Oxidants
Comments/Corrections

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