Document Detail

Dietary acrylamide exposure and hemoglobin adducts--National Health and Nutrition Examination Survey (2003-04).
MedLine Citation:
PMID:  20696196     Owner:  NLM     Status:  MEDLINE    
The objective of this study is to evaluate the relationship between dietary AA and hemoglobin adducts using the National Health and Nutrition Examination Survey (NHANES, 2003-04). Measured acrylamide (AA-Hb) and glycidamide (Gly-Hb) hemoglobin adducts for over 7000 participants >3 years, 24-h dietary recall, food frequency questionnaire (FFQ), lifestyle and demographic data, and anthropometric measurements are available from NHANES (2003-04). The 24-h dietary recall and FFQ data were combined with AA concentration data in food from the US FDA to estimate "usual" AA dietary exposure. The associations between dietary AA and AA-Hb and Gly-Hb were evaluated using linear regression models with smoking, age, gender, energy and macronutrient intake, body surface area, and activity level as covariates. Dietary AA positively correlates with AA-Hb and Gly-Hb (p<0.05) but the correlation is small (R-Squared<3.5%). Relative to the background adduct levels, the incremental increase in AA-Hb and Gly-Hb from average dietary AA is small (7% and 9% for AA-Hb and Gly-Hb, respectively). Non-dietary sources of exposure, measurement errors associated with the use of the FFQ, and uncertainty in the data on AA levels in foods are possible explanations for the observed lack of association between dietary AA and AA-Hb and Gly-Hb.
N L Tran; L M Barraj; M M Murphy; X Bi
Related Documents :
16234836 - Flavonoid classes and risk of peripheral arterial occlusive disease: a case-control stu...
10656476 - Does nutritionist review of a self-administered food frequency questionnaire improve da...
8694736 - Association of zinc and antioxidant nutrients with age-related maculopathy.
6255056 - Assessment of the intake of dietary fibre from cereal foods: an epidemiological approach.
16786876 - Aflatoxin b1 contamination in wheat grain samples collected from different geographical...
9031426 - Food-borne nitrates and nitrites as a cause of methemoglobinemia.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-07
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3098-108     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
E(x)ponent®, Inc., Washington, DC 20036, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acrylamide / administration & dosage*,  adverse effects,  metabolism*
Biological Markers / blood
Child, Preschool
Cotinine / blood
Environmental Exposure / adverse effects
Epoxy Compounds / metabolism
Food Contamination / analysis*
Food Habits
Health Surveys
Hemoglobins / metabolism*
Nutrition Surveys
United States
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Epoxy Compounds; 0/Hemoglobins; 486-56-6/Cotinine; 5694-00-8/glycidamide; 79-06-1/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Amyloid precursor protein gene mutated at Swedish 670/671 sites in vitro induces changed expression ...
Next Document:  Towards the re-introduction of grass pea (Lathyrus sativus) in the West Balkan Countries: The case o...