Document Detail


Dietary acrylamide exposure and hemoglobin adducts--National Health and Nutrition Examination Survey (2003-04).
MedLine Citation:
PMID:  20696196     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study is to evaluate the relationship between dietary AA and hemoglobin adducts using the National Health and Nutrition Examination Survey (NHANES, 2003-04). Measured acrylamide (AA-Hb) and glycidamide (Gly-Hb) hemoglobin adducts for over 7000 participants >3 years, 24-h dietary recall, food frequency questionnaire (FFQ), lifestyle and demographic data, and anthropometric measurements are available from NHANES (2003-04). The 24-h dietary recall and FFQ data were combined with AA concentration data in food from the US FDA to estimate "usual" AA dietary exposure. The associations between dietary AA and AA-Hb and Gly-Hb were evaluated using linear regression models with smoking, age, gender, energy and macronutrient intake, body surface area, and activity level as covariates. Dietary AA positively correlates with AA-Hb and Gly-Hb (p<0.05) but the correlation is small (R-Squared<3.5%). Relative to the background adduct levels, the incremental increase in AA-Hb and Gly-Hb from average dietary AA is small (7% and 9% for AA-Hb and Gly-Hb, respectively). Non-dietary sources of exposure, measurement errors associated with the use of the FFQ, and uncertainty in the data on AA levels in foods are possible explanations for the observed lack of association between dietary AA and AA-Hb and Gly-Hb.
Authors:
N L Tran; L M Barraj; M M Murphy; X Bi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-07
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3098-108     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
E(x)ponent®, Inc., Washington, DC 20036, USA. ntran@exponent.com
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MeSH Terms
Descriptor/Qualifier:
Acrylamide / administration & dosage*,  adverse effects,  metabolism*
Adolescent
Adult
Biological Markers / blood
Child
Child, Preschool
Cotinine / blood
Diet
Eating
Environmental Exposure / adverse effects
Epoxy Compounds / metabolism
Female
Food Contamination / analysis*
Food Habits
Health Surveys
Hemoglobins / metabolism*
Humans
Male
Nutrition Surveys
Questionnaires
United States
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Epoxy Compounds; 0/Hemoglobins; 486-56-6/Cotinine; 5694-00-8/glycidamide; 79-06-1/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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