| Diet supplemented with yoghurt or milk fermented by Lactobacillus casei DN-114 001 stimulates growth and brush-border enzyme activities in mouse small intestine. | |
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MedLine Citation:
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PMID: 9693207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nutritional benefits of lactic acid bacteria in fermented dairy products have been well documented, especially in terms of weight gain and feed efficiency, but not in terms of small intestine adaptation. The effects of a diet supplemented (30% wt/wt) with milk fermented either by Lactobacillus casei DN-114 001 or yoghurt for 3 or 15 days were investigated in the small intestine of mice by morphometry, kinetic analysis and determination of brush-border enzyme activities. Results were compared with those obtained with standard or milk isocaloric diets. Cell proliferation and villous area were significantly increased in the proximal intestine of mice fed the fermented-milk-supplemented diets for 3 days and were associated with hypertrophy and hyperplasia of Paneth and goblet cells. Lactase-specific activity was increased by fermented-milk diets at days 3 and 15, whereas there was no variation in maltase-specific activity. Alkaline phosphatase-specific activity was increased after 3 days of the three tested diets in the whole intestine, and after 15 days in the proximal intestine. Aminopeptidase activity was increased in the distal part of the intestine after 3 days of the 3 diets. Our findings suggest that diets supplemented with fermented milks have a positive effect on the trophicity of the mucosa in the small intestine of mice. |
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Authors:
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K Thoreux; D Balas; C Bouley; F Senegas-Balas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestion Volume: 59 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 1998 Jul-Aug |
Date Detail:
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Created Date: 1998-09-09 Completed Date: 1998-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 349-59 Citation Subset: IM |
Affiliation:
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Laboratoire d'Histologie, Faculté de Médecine, Nice, France. thoreux@unice.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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metabolism Animals Body Weight Cell Division Dietary Supplements* Hydrolases / metabolism* Intestinal Mucosa / cytology, enzymology Intestine, Small / cytology*, enzymology Lactase Lactobacillus casei Mice Microvilli / enzymology* Milk* Weight Gain Yogurt* beta-Galactosidase / metabolism |
| Chemical | |
Reg. No./Substance:
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EC 3.-/Hydrolases; EC 3.1.3.1/Alkaline Phosphatase; EC 3.2.1.108/Lactase; EC 3.2.1.23/beta-Galactosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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