| Diet, nutrition, and cancer. An update on a controversial relationship. | |
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MedLine Citation:
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PMID: 2989809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The multiple-step model of carcinogenesis discussed here identifies the two major stages of initiation and promotion. A more recent research development proposes that oncogenes present in chromosomes are activated by viral, chemical, or physical agents and cause cancer. A great variety of natural mutagens and carcinogens find their way into the modern US diet. Excessive fat and alcohol consumption have been studied in relation to many kinds of malignancies. Dietary anticarcinogens include vitamins A, C, and E, although under certain conditions some generally inhibitive substances can actually enhance carcinogenesis. A provocative hypothesis argues that a high-fiber diet can substantially reduce the likelihood of carcinoma of the colon. |
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Authors:
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D T Purtilo; S M Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Postgraduate medicine Volume: 78 ISSN: 0032-5481 ISO Abbreviation: Postgrad Med Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-20 Completed Date: 1985-08-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0401147 Medline TA: Postgrad Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-4, 199-203 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxins
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adverse effects Ascorbic Acid / therapeutic use Carcinogens Diet* / adverse effects Dietary Fats / adverse effects Dietary Fiber / administration & dosage Ethanol / adverse effects Humans Liver Neoplasms / chemically induced Neoplasms / chemically induced, etiology*, prevention & control Nitrogen Oxides / adverse effects Nutritional Physiological Phenomena* Oncogenes Retinoids / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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CA28015/CA/NCI NIH HHS; CA30196/CA/NCI NIH HHS; CA32313/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Carcinogens; 0/Dietary Fats; 0/Nitrogen Oxides; 0/Retinoids; 50-81-7/Ascorbic Acid; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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