Document Detail

Diet of lactating women and allergic reactions in their infants.
MedLine Citation:
PMID:  16607130     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To evaluate whether the diet of lactating women modulates the development of allergic disease in their children. RECENT FINDINGS: Although maternal avoidance of common food protein allergens was previously recommended for lactating women with infants predisposed to allergic disease, recent expert reviews have concluded that there is no strong evidence to support this position. A recent well-controlled study, using egg as an allergen, confirmed that the appearance of food proteins in human milk is common, but this can be highly variable between women even after consuming the same challenge (dose) food. On the other hand, preliminary data suggest that increasing dietary n-3 fatty acids may offer protection from the development of some childhood allergies. A recent animal study offers mechanistic support, indicating that perinatal diets high in n-3 fatty acids can induce oral neonatal tolerance more effectively compared with diets predominating in n-6 fatty acids. SUMMARY: Current data do not support the use of maternal antigen-avoidance diets during lactation as a strategy to prevent childhood allergies. Controlled trials are required to evaluate the efficacy of maternal dietary n-3 fatty acid interventions in preventing allergic disease in at-risk infants.
Debra Jane Palmer; Maria Makrides
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  9     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-11     Completed Date:  2006-10-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  284-8     Citation Subset:  IM    
Child Health Research Institute, and Department of Paediatrics, The University of Adelaide, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
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MeSH Terms
Controlled Clinical Trials as Topic
Fatty Acids, Omega-3 / metabolism
Hypersensitivity / prevention & control*
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Lactation / immunology,  metabolism,  physiology*
Maternal Nutritional Physiological Phenomena / physiology*
Milk Proteins / immunology,  metabolism
Primary Prevention
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Milk Proteins

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