| Diet-induced obesity in Sca-1 KO mice. | |
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MedLine Citation:
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PMID: 21510817 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Stem Cell Antigen-1 (Sca-1) is a member of the Ly6 family and has served as a marker for the identification of stem cells in various tissues, including fat depots. In vitro and in vivo studies suggest the possible involvement of Sca-1 in adipogenic differentiation and link Sca-1 antigenicity with adipocyte progenitors. Previously we showed that Sca-1 enriched populations of ear mesenchymal stem cells possess enhanced capacity to differentiate into adipocytes. Additionally we determined the natural frequency and localization of Sca-1 positive progenitor/stem cells in brown and white fat in situ. The present study addressed the question whether Sca-1 deficiency alters the white adipose tissue response to a high saturated fat diet. Our results show that Sca-1 null mice (Sca-1-/-) fed high fat diet developed obesity equally well as wild type mice suggesting either an indirect in vivo effect of Sca-1 or a compensatory response to Sca-1 deficiency. However, contrary to wild type mice, high fat diet fed Sca-1-/- mice showed no alterations in serum adipocytokines. The data leads to the conclusion that Sca-1 is either redundant or a non-essential marker of adipose progenitor/stem cells. Nevertheless, since Sca-1 deficient mice displayed elevated blood glucose at fasting, exhibited glucose intolerance and insulin resistance, Sca-1 has subtle effects on adipose function. Thus, the Sca-1 deficient mice may provide a useful model for metabolic studies. |
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Authors:
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Jaroslaw Staszkiewicz; Jeffrey Gimble; Marilyn A Dietrich; Barbara Gawronska-Kozak |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-21 |
Journal Detail:
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Title: Stem cells and development Volume: - ISSN: 1557-8534 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197107 Medline TA: Stem Cells Dev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Pennington Biomedical Research Center, Regenerative Biology Laboratory, Baton Rouge, Louisiana, United States; StaszkJ@pbrc.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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