| Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression at bile canaliculi. | |
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MedLine Citation:
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PMID: 21628838 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The ATP-binding cassette half-transporters Abcg5 and Abcg8 promote the secretion of neutral sterols into bile. Studies have demonstrated the diet-induced expression of these transporters in liver, though precisely where this occurs remains to be elucidated. This study investigated the changes in the expression of these transporters at bile canaliculi in cholesterol-loaded livers. Mice were fed either a standard (SD) diet or a high-fat and high-sucrose (HF/HS) diet for 3 weeks. Bile canaliculi proteins and cryosections were prepared from the liver, and the protein levels and distribution of Abcg5/Abcg8 were determined. The high-calorie diet induced a marked accumulation of lipids in mouse liver. Protein levels of Abcg5 and Abcg8 in bile canaliculi were significantly increased by the HF/HS diet compared to the SD diet. No significant differences in Abca1, Abcb4 (Mdr2), Abcb11 (Bsep) and Abcc2 (Mrp2) levels were observed. Immunohistochemical analyses confirmed the increases occurred in bile canaliculi. These results suggest that diet-induced lipid loading into liver causes a significant increase in the expression of Abcg5 and Abcg8 in bile canaliculi. |
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Authors:
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Yasuhiro Yamazaki; Takahiro Hashizume; Hiroko Morioka; Satoshi Sadamitsu; Akira Ikari; Masao Miwa; Junko Sugatani |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-31 |
Journal Detail:
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Title: Drug metabolism and pharmacokinetics Volume: - ISSN: 1880-0920 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-6-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101164773 Medline TA: Drug Metab Pharmacokinet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pharmaco-Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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