Document Detail

Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female.
MedLine Citation:
PMID:  17551099     Owner:  NLM     Status:  MEDLINE    
The effects of nonmutagenic environmental exposures can sometimes be transmitted for several generations, suggesting transgenerational inheritance of induced epigenetic variation. Methyl donor supplementation of female mice during pregnancy induces CpG hypermethylation at the agouti viable yellow (A(vy)) allele in A(vy)/a offspring. Epigenetic inheritance occurs at A(vy); when passed through the female germ line, A(vy) epigenotype is not completely "reset." We therefore tested whether diet-induced epigenetic alterations at A(vy) are inherited transgenerationally. Female A(vy)/a mice were weaned onto either control (n=6) or a methyl-supplemented diet (n=5). These F0 dams were mated with a/a males. All F1 and F2 A(vy)/a females were weaned onto the same diet as their mothers, then mated with a/a males. F1, F2, and F3 A(vy)/a offspring were classified for coat color, an indicator of A(vy) methylation. In total, 62 F1, 98 F2, and 209 F3 A(vy)/a mice were studied. As expected, average A(vy)/a coat color was darker in the supplemented group (P<0.01). However, there was no cumulative effect of supplementation across successive generations. These results suggest that, in the female germ line, diet-induced A(vy) hypermethylation occurs in the absence of additional epigenetic modifications that normally confer transgenerational epigenetic inheritance at the locus.
Robert A Waterland; Michael Travisano; Kajal G Tahiliani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-06-05
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  21     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-01-07     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3380-5     Citation Subset:  IM    
Department of Pediatrics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, TX 77030, USA.
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MeSH Terms
Agouti Signaling Protein / genetics*
CpG Islands
DNA Methylation*
Dietary Supplements
Epigenesis, Genetic*
Hair Color / genetics*
Mice, Inbred C3H
Mice, Inbred C57BL
Random Allocation
Grant Support
Reg. No./Substance:
0/Agouti Signaling Protein; 0/nonagouti protein, mouse
Comment In:
FASEB J. 2007 Oct;21(12):3021; author reply 3021-2   [PMID:  17905729 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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