| Diet-induced hypercholesterolemia impaired testicular steroidogenesis in mice through the renin-angiotensin system. | |
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MedLine Citation:
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PMID: 21536044 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hypercholesterolemia and low testosterone concentrations in men are associated with a high risk factor for atherosclerosis. It is known that cholesterol serves as the major precursor for the synthesis of the sex hormones. The bioactive peptides of the renin-angiotensin-system localized in the gonads play a key role in the relation between cholesterol and testosterone by modulating steroidogenesis and inhibiting testosterone production. In the present work, we evaluated the effects of diet-induced hypercholesterolemia on circulating testosterone levels and its relationship with the testicular RAS-regulating specific aminopeptidase activities in male mouse. A significant decrease in serum circulating levels of testosterone was observed after induced hypercholesterolemia. The changes found in aminopeptidase activities suggest a role of Ang III and Ang IV in the regulation of steroidogenesis. |
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Authors:
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José M Martínez-Martos; Marce Arrazola; María D Mayas; María P Carrera-González; María J García; María J Ramírez-Expósito |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-23 |
Journal Detail:
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Title: General and comparative endocrinology Volume: - ISSN: 1095-6840 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370735 Medline TA: Gen Comp Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Experimental and Clinical Physiopathology Research Group BIO296, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Jaén, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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