Document Detail

Diet-induced endothelial dysfunction in the rat is independent of the degree of increase in total body weight.
MedLine Citation:
PMID:  11352779     Owner:  NLM     Status:  MEDLINE    
A growing number of studies indicate an association between obesity, insulin resistance, dyslipidaemia and cardiovascular disorders, collectively known as Syndrome X. In this study we have aimed to produce a model of Syndrome X by voluntary feeding of Wistar rats with a highly palatable cafeteria diet, and examined its effects on metabolic changes and vascular reactivity of Wistar rats. At the end of the experiment, the cafeteria-diet fed group was divided into two groups of low weight gain (LWG) and high weight gain (HWG). Both LWG and HWG groups had significantly (P<0.01) higher fat-pad mass than their chow-fed counterparts, while gastrocnemius muscle mass were comparable. All cafeteria-diet fed rats had significantly (P<0.01) raised plasma triacylglycerol (TG) levels whereas plasma non-esterified fatty acids, glucose and insulin levels were similar between chow-fed and cafeteria-diet fed rats. Vasorelaxation responses to acteylcholine, insulin and sodium nitroprusside were significantly (P<0.01) attenuated in cafeteria-diet fed animals; however, there were no differences in contractile responses of the mesenteric arteries to noradrenaline or KCl between the groups. Multiple regression analysis showed a significant (P<0.05) negative association between plasma TG levels and reduction in acetylcholine-induced vasorelaxation. Acetylcholine-induced vasorelaxation was also significantly (P<0.05) associated with the amount of fat-pad mass. These data suggest that diet-induced vascular dysfunction can occur in the absence of insulin resistance, and that plasma TGs may have a detrimental effect on vascular reactivity.
E K Naderali; L C Pickavance; J P Wilding; G Williams
Related Documents :
17592939 - Early impact of a fat-enriched diet on behavioral responses of male and female rats.
874569 - Influence of estrogen treatment on hepatic cystathionine synthase and cystathionase of ...
21214019 - Fermented liquid feed for pigs.
20186659 - Development of glucose intolerance in wistar rats fed low and moderate fat diets differ...
19491299 - Comp-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice.
7042319 - Effect of high fat and high carbohydrate diets on adipose tissue pyruvate dehydrogenase...
19376839 - Analyzing serum-stimulated prostate cancer cell lines after low-fat, high-fiber diet an...
18691839 - Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, ...
22752159 - Consumption of lysozyme-rich milk can alter microbial fecal populations.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  100     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-15     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  635-41     Citation Subset:  IM    
Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, UCD, Daulby Street, Liverpool L693GA, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diet / adverse effects*
Disease Models, Animal
Dose-Response Relationship, Drug
Endothelium, Vascular / physiopathology*
Insulin / pharmacology
Microvascular Angina / physiopathology*
Obesity / physiopathology*
Rats, Wistar
Triglycerides / blood
Vasoconstriction / physiology
Vasodilation / drug effects,  physiology
Weight Gain / physiology
Reg. No./Substance:
0/Triglycerides; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal a...
Next Document:  Muscle afferent and central command contributions to the cardiovascular response to isometric exerci...