Document Detail


Diet-induced endothelial dysfunction in the rat is independent of the degree of increase in total body weight.
MedLine Citation:
PMID:  11352779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A growing number of studies indicate an association between obesity, insulin resistance, dyslipidaemia and cardiovascular disorders, collectively known as Syndrome X. In this study we have aimed to produce a model of Syndrome X by voluntary feeding of Wistar rats with a highly palatable cafeteria diet, and examined its effects on metabolic changes and vascular reactivity of Wistar rats. At the end of the experiment, the cafeteria-diet fed group was divided into two groups of low weight gain (LWG) and high weight gain (HWG). Both LWG and HWG groups had significantly (P<0.01) higher fat-pad mass than their chow-fed counterparts, while gastrocnemius muscle mass were comparable. All cafeteria-diet fed rats had significantly (P<0.01) raised plasma triacylglycerol (TG) levels whereas plasma non-esterified fatty acids, glucose and insulin levels were similar between chow-fed and cafeteria-diet fed rats. Vasorelaxation responses to acteylcholine, insulin and sodium nitroprusside were significantly (P<0.01) attenuated in cafeteria-diet fed animals; however, there were no differences in contractile responses of the mesenteric arteries to noradrenaline or KCl between the groups. Multiple regression analysis showed a significant (P<0.05) negative association between plasma TG levels and reduction in acetylcholine-induced vasorelaxation. Acetylcholine-induced vasorelaxation was also significantly (P<0.05) associated with the amount of fat-pad mass. These data suggest that diet-induced vascular dysfunction can occur in the absence of insulin resistance, and that plasma TGs may have a detrimental effect on vascular reactivity.
Authors:
E K Naderali; L C Pickavance; J P Wilding; G Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  100     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-15     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  635-41     Citation Subset:  IM    
Affiliation:
Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, UCD, Daulby Street, Liverpool L693GA, UK. naderali@liverpool.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Diet / adverse effects*
Disease Models, Animal
Dose-Response Relationship, Drug
Endothelium, Vascular / physiopathology*
Female
Insulin / pharmacology
Microvascular Angina / physiopathology*
Obesity / physiopathology*
Rats
Rats, Wistar
Triglycerides / blood
Vasoconstriction / physiology
Vasodilation / drug effects,  physiology
Weight Gain / physiology
Chemical
Reg. No./Substance:
0/Triglycerides; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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