Document Detail

Diet-induced changes in selected clinical chemistry parameters in M. fascicularis.
MedLine Citation:
PMID:  4081317     Owner:  NLM     Status:  MEDLINE    
Thirty-six male M. fascicularis monkeys were fed a basal diet (180 g/day, 24% protein, 38% carbohydrate and 20% fat) for a period of 17 months. At that time, the animals were divided into two groups. One group (6 animals) continued on the basal diet (BASAL group), while the others (30 animals) received an atherogenic diet (ATHER group) containing 4.08 g/kg cholesterol. Blood samples were drawn for clinical chemistry analyses. Serum cholesterol rose dramatically in the ATHER group, an average increase of 350 mg/dl over basal-diet values after two weeks on the atherogenic diet. Serum triglycerides followed the same pattern. HDL-cholesterol in the atherogenic-diet group decreased sharply. These animals also had slightly elevated BUN, uric acid and SGOT levels. Skin lipid xanthomas were also observed in the ATHER group, but were absent in animals fed the basal diet. Body weight among all animals remained relatively constant. Minimal changes in clinical chemistry values other than those noted above are evidence of the low physiological stress placed on the animals by this dietary regimen.
M J Bush; A J Verlangieri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  50     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-02-19     Completed Date:  1986-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-79     Citation Subset:  IM    
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MeSH Terms
Aspartate Aminotransferases / blood
Blood Urea Nitrogen
Body Weight
Cholesterol / blood
Diet, Atherogenic*
Macaca fascicularis
Time Factors
Triglycerides / blood
Uric Acid / blood
Reg. No./Substance:
0/Triglycerides; 57-88-5/Cholesterol; 69-93-2/Uric Acid; EC Aminotransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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