Document Detail


Diet-induced changes in glucose and triglycerides are associated with changes in plasminogen activator inhibitor levels.
MedLine Citation:
PMID:  1837785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-four healthy female subjects volunteered to participate in an experiment in which they maintained a high-fat/low-carbohydrate (CHO) diet followed by a low-fat/high-CHO diet or vice versa in a cross-over study design. In bivariate correlation analysis, only glucose (r = 0.52, p less than 0.05) and triglycerides (r = 0.53, p less than 0.05) correlated with changes in plasminogen activator inhibitor type 1 (PAI-1) activity. A second-degree polynomial response surface model suggested that transition from a high-fat/low-CHO diet to a low-fat/high-CHO diet is associated with reduced levels of PAI-1 provided that glucose and triglyceride levels are not elevated by more than 1.2 and 0.5 mmol/l, respectively.
Authors:
I B Sundell; G H Dahlén; M Rånby
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Haemostasis     Volume:  21     ISSN:  0301-0147     ISO Abbreviation:  Haemostasis     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-04     Completed Date:  1992-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0371574     Medline TA:  Haemostasis     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism*
Dietary Carbohydrates / pharmacology*
Dietary Fats / pharmacology*
Female
Humans
Hydrocortisone / urine
Insulin / blood
Lipids / blood*
Lipoprotein(a)
Lipoproteins / blood
Plasminogen / metabolism
Plasminogen Inactivators / blood*
Tissue Plasminogen Activator / immunology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipids; 0/Lipoprotein(a); 0/Lipoproteins; 0/Plasminogen Inactivators; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 9001-91-6/Plasminogen; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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