Document Detail


Diet-induced alterations in intestinal and extrahepatic lipid metabolism in liver fatty acid binding protein knockout mice.
MedLine Citation:
PMID:  19116776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol. L-fabp (-/-) mice were protected against obesity and hepatic steatosis on a high saturated fat (SF), high cholesterol "Western" diet and manifested a similar phenotype when fed with a high SF, low cholesterol diet. There were no significant differences in fecal fat content or food consumption between the genotypes, and fatty acid (FA) oxidation was reduced, rather than increased, in SF-fed L-fabp (-/-) mice as evidenced by decreased heat production and serum ketones. In contrast to mice fed with a SF diet, L-fabp (-/-) mice fed with a high PUFA diet were not protected against obesity and hepatic steatosis. These observations together suggest that L-fabp (-/-) mice exhibit a specific defect in the metabolism of SFA, possibly reflecting altered kinetics of FA utilization. In support of this possibility, microarray analysis of muscle from Western diet-fed mice revealed alterations in genes regulating glucose uptake and FA synthesis. In addition, intestinal cholesterol absorption was decreased in L-fabp (-/-) mice. On the other hand, and in striking contrast to other reports, female L-fabp (-/-) mice fed with low fat, high cholesterol diets gained slightly less weight than control mice, with minor reductions in hepatic triglyceride content. Together these data indicate a role for L-FABP in intestinal trafficking of both SFA and cholesterol.
Authors:
Elizabeth P Newberry; Susan M Kennedy; Yan Xie; Jianyang Luo; Nicholas O Davidson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-12-31
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  326     ISSN:  1573-4919     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-09-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-86     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholesterol / metabolism*
Diet*
Dietary Fats / metabolism
Fatty Acid-Binding Proteins / genetics*,  metabolism
Fatty Acids / metabolism*
Fatty Liver / metabolism
Female
Gene Expression
Intestines / metabolism*
Lipid Metabolism / genetics
Liver / metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Obesity / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
DK-52574/DK/NIDDK NIH HHS; DK-56260/DK/NIDDK NIH HHS; HL-38180/HL/NHLBI NIH HHS; P30 DK-56341/DK/NIDDK NIH HHS; P30 DK052574-11/DK/NIDDK NIH HHS; P30 DK056341-07/DK/NIDDK NIH HHS; P30 DK056341-08/DK/NIDDK NIH HHS; P60 DK-020579-30/DK/NIDDK NIH HHS; R01 DK056260-11/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids; 57-88-5/Cholesterol
Comments/Corrections

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