Document Detail

Diet in late pregnancy and glucose-insulin metabolism of the offspring 40 years later.
MedLine Citation:
PMID:  10901561     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine how diets of women in pregnancy influence the glucose-insulin metabolism of their offspring in adult life. DESIGN: A follow up study of men and women born during 1948-1954 whose mothers had taken part in a survey of diet in late pregnancy. SETTING: Aberdeen, Scotland. POPULATION: One hundred and sixty-eight men and women born in the Aberdeen Maternity Hospital. MAIN OUTCOME MEASURE: Plasma glucose and insulin concentrations, fasting and after a standard oral glucose challenge. RESULTS: The offspring of women who had high intakes of fat and protein in late pregnancy had a reduced plasma insulin increment between fasting and 30 min with a 7.0% decrease in increment (P = 0.007) per 10 g increase in protein intake and a 4.9% decrease (P = 0.002) per 10 g increase in fat intake. This was independent of the mother's body mass index or weight gain in pregnancy. A low maternal body mass index in early or late pregnancy was associated with a raised fasting plasma insulin concentration with a decrease of 2.4% (P = 0.05) per 1 kg/m2 increase of maternal body mass. CONCLUSION: High intakes of protein and fat during pregnancy may impair development of the fetal pancreatic beta cells and lead to insulin deficiency in the offspring. The offspring of thin mothers tend to be insulin resistant.
A W Shiell; D M Campbell; M H Hall; D J Barker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  107     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-07-27     Completed Date:  2000-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  890-5     Citation Subset:  AIM; IM    
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK.
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MeSH Terms
Birth Weight / physiology
Blood Glucose / metabolism*
Blood Pressure / physiology
Body Mass Index
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage
Energy Intake / physiology
Follow-Up Studies
Insulin / blood*
Middle Aged
Pregnancy / metabolism*
Scotland / epidemiology
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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