Document Detail

Diet: friend or foe of enteroendocrine cells--how it interacts with enteroendocrine cells.
MedLine Citation:
PMID:  22332097     Owner:  NLM     Status:  MEDLINE    
Gut hormones play a key role in the regulation of food intake, energy expenditure, glucose homeostasis, lipid metabolism, and a wide range of metabolic functions in response to food ingestion. These hormones are altered in metabolic diseases, such as obesity and type 2 diabetes, and are thus proposed to be possible targets for the prevention or treatment of these diseases. It is clear that food composition, macronutrients, and other non-nutrient components as well as the physical properties of food not only modulate the secretion of gut peptides but also modulate transcription and enteroendocrine cell differentiation, which ultimately modifies gut hormone response. The specific mechanisms or sensing machinery that respond to the different components of the diet have been studied for many years; however, over the last few years, new molecular genetic techniques have led to important advances, thereby allowing a deeper understanding of these mechanisms. This review addresses the current knowledge regarding enteroendocrine cells and how diet interacts with this machinery to stimulate and regulate the secretion of gut peptides. The potential for diet interventions as a promising strategy for modulating gut hormone responses to food ingestion and, ultimately, preventing or treating metabolic diseases is being emphasized considering that these diseases are currently a public health burden.
Sofia Moran-Ramos; Armando R Tovar; Nimbe Torres
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-05
Journal Detail:
Title:  Advances in nutrition (Bethesda, Md.)     Volume:  3     ISSN:  2156-5376     ISO Abbreviation:  Adv Nutr     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-06-14     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101540874     Medline TA:  Adv Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-20     Citation Subset:  IM    
Departamento de Fisiología de la Nutrición Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.
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MeSH Terms
Diabetes Mellitus, Type 2 / metabolism
Enteroendocrine Cells / metabolism*,  physiology
Gastrointestinal Hormones / secretion*
Gastrointestinal Tract / metabolism*,  physiology
Obesity / metabolism
Reg. No./Substance:
0/Gastrointestinal Hormones

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