| Diet and expression of estrogen alpha and progesterone receptors in malignant mammary tissue. | |
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MedLine Citation:
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PMID: 21170813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Estrogen receptor (ER) and/or progesterone receptor (PR) expression has been associated with more favorable breast cancer prognosis. Results on the differential association of diet with ER and/or PR positive and negative tumors have been inconclusive. In a large case-control study conducted in Athens, Greece, we investigated whether diet is associated with the expression of ER-alpha or PR in mammary tumors of 421 women with histologically confirmed breast cancer. Diet was assessed through an extensive food frequency questionnaire and results were analyzed using multiple logistic regression. After controlling for non-nutritional variables and mutually adjusting for energy-generating nutrients and ethanol, carbohydrate intake was inversely associated with ER-alpha (P = 0.04) and PR (P = 0.10) expression. The odds ratios (OR) per one standard deviation increment were 0.69 with 95% confidence interval (95% CI) 0.48-0.98 for ER-alpha and 0.72 (95% CI 0.49-1.07) for PR expression. No consistent or statistically significant associations were noted for any of the other energy-generating nutrients or food groups examined. Although in these data no strong relations of qualitative aspects of diet with hormone receptor expression in breast cancer tumors were evident, the inverse association of carbohydrate intake with ER-alpha, and perhaps PR, expression merits further study in future investigations. |
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Authors:
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Areti Lagiou; Evangelia Samoli; Christina Georgila; Pantelina Zourna; Anastasia Barbouni; Dorothy Vassilarou; Annivas Tsikkinis; Constantine E Sekeris; Dimitrios Trichopoulos; Pagona Lagiou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition and cancer Volume: 63 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-17 Completed Date: 2011-05-03 Revised Date: 2011-09-02 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: England |
Other Details:
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Languages: eng Pagination: 65-72 Citation Subset: IM |
Affiliation:
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Department of Hygiene, Epidemiology and Biostatistics, University of Athens Medical School, Goudi, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast Neoplasms / chemistry* Diet* Dietary Carbohydrates / administration & dosage Female Humans Logistic Models Middle Aged Nuclear Proteins / analysis* Receptors, Progesterone / analysis* Transcription Factors / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/MIER1 protein, human; 0/Nuclear Proteins; 0/Receptors, Progesterone; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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