| Diet and exercise in an obese mouse fed a high fat diet improves metabolic health and reverses perturbed sperm function. | |
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MedLine Citation:
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PMID: 22252945 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Male obesity is associated with reduced sperm motility, morphology and increased sperm DNA damage and oxidative stress; however, the reversibility of these phenotypes has never been studied. Therefore the aim of this study was to assess the reversibility of obesity and its associated sperm physiology and function in mice in response to weight loss through diet and exercise. C57BL6 male mice (n=40) were fed either a control diet (CD) (6% fat) or a high fat diet (HFD) (21% fat) for a period of 10 weeks before allocation to either diet and/or swimming exercise interventions for a period of 8 weeks. Diet alone reduced adiposity (1.6 fold) and serum cholesterol levels (1.7 fold, p<0.05), while exercise alone did not alter these, with exercise and diet also improved glucose tolerance (1.3 fold, p<0.05). Diet and/or exercise improved sperm motility (1.2 fold) and morphology (1.1 fold, p<0.05), reduced sperm DNA damage (1.5 fold), reactive oxygen species (1.1 fold) and mitochondrial membrane potential (1.2 fold, p<0.05) and increased sperm binding (1.4 fold) (p<0.05). Sperm parameters were highly correlated with measures of glycaemia, insulin action and serum cholesterol (all p<0.05), regardless of adiposity or intervention, suggesting a link between systemic metabolic status and sperm function. This is the first study to show that the abnormal sperm physiology resulting from obesity can be reversed through diet and exercise, even in the presence of on-going obesity, suggesting that diet and lifestyle interventions could be a combined approach to target sub fertility in overweight and obese men. |
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Authors:
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Nicole O Palmer; Hassan W Bakos; Julie A Owens; Brian P Setchell; Michelle Lane |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: - ISSN: 1522-1555 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Adelaide. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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