| Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. | |
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MedLine Citation:
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PMID: 21596990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coevolution of mammals and their gut microbiota has profoundly affected their radiation into myriad habitats. We used shotgun sequencing of microbial community DNA and targeted sequencing of bacterial 16S ribosomal RNA genes to gain an understanding of how microbial communities adapt to extremes of diet. We sampled fecal DNA from 33 mammalian species and 18 humans who kept detailed diet records, and we found that the adaptation of the microbiota to diet is similar across different mammalian lineages. Functional repertoires of microbiome genes, such as those encoding carbohydrate-active enzymes and proteases, can be predicted from bacterial species assemblages. These results illustrate the value of characterizing vertebrate gut microbiomes to understand host evolutionary histories at a supraorganismal level. |
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Authors:
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Brian D Muegge; Justin Kuczynski; Dan Knights; Jose C Clemente; Antonio González; Luigi Fontana; Bernard Henrissat; Rob Knight; Jeffrey I Gordon |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 332 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-20 Completed Date: 2011-06-03 Revised Date: 2012-04-12 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 970-4 Citation Subset: IM |
Affiliation:
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Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Amino Acids / biosynthesis Animals Bacteria / classification, genetics, metabolism Biological Evolution Biostatistics Caloric Restriction Diet* Enzymes / genetics, metabolism Feces / microbiology* Gastrointestinal Tract / microbiology*, physiology Genes, Bacterial Genes, rRNA Humans Least-Squares Analysis Mammals / microbiology*, physiology Metagenome / physiology* Monte Carlo Method Phylogeny* Proteins / metabolism RNA, Ribosomal, 16S / genetics Sequence Analysis, DNA |
| Grant Support | |
ID/Acronym/Agency:
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DK078669/DK/NIDDK NIH HHS; DK30292/DK/NIDDK NIH HHS; DK70977/DK/NIDDK NIH HHS; P01 DK078669-05/DK/NIDDK NIH HHS; P30 DK056341-11/DK/NIDDK NIH HHS; R01 DK070977-08/DK/NIDDK NIH HHS; R37 DK030292-31/DK/NIDDK NIH HHS; T32-A1007172//PHS HHS; UL1 RR024992/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Enzymes; 0/Proteins; 0/RNA, Ribosomal, 16S |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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