| Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. | |
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MedLine Citation:
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PMID: 20843485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: EPIC is a multicentre prospective study carried out in 23 centres in 10 European countries: Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden and the United Kingdom, including 519,978 participants (366,521 women and 153,457 men), most aged 35-70 years. RESULTS: We observed the following significant associations: gastric cancer risk was inversely associated with high plasma vitamin C, some carotenoids, retinol and α-tocopherol, high intake of cereal fibre and high adhesion to Mediterranean diet, while red and processed meat were associated with increased risk. High intake of dietary fibre, fish, calcium, and plasma vitamin D were associated with a decreased risk of colorectal cancer, while red and processed meat intake, alcohol intake, body mass index (BMI) and abdominal obesity were associated with an increased risk. High intake of fruit and vegetables in current smokers were associated with a decreased risk of lung cancer. An increased risk of breast cancer was associated with high saturated fat intake and alcohol intake. In postmenopausal women, BMI was positively and physical activity negatively associated with breast cancer risk. High intake of dairy protein and calcium from dairy products and high serum concentration of IGF-I were associated with an increased risk of prostate cancer. These results contribute to scientific evidence for appropriate public health strategies and prevention activities aimed at reducing the global cancer burden. |
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Authors:
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Carlos A Gonzalez; Elio Riboli |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cancer (Oxford, England : 1990) Volume: 46 ISSN: 1879-0852 ISO Abbreviation: Eur. J. Cancer Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-04 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9005373 Medline TA: Eur J Cancer Country: England |
Other Details:
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Languages: eng Pagination: 2555-62 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Unit of Nutrition, Environment and Cancer, Programme of Epidemilogical Cancer Research, Institut Català d'Oncologia, Av. Gran Via s/n, km 2.7, 08907 L'Hospitalet, Barcelona, Spain. cagonzalez@iconcologia.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Diet / statistics & numerical data* Dietary Fiber Europe / epidemiology Female Food / statistics & numerical data* Fruit Humans Male Meat Products Middle Aged Neoplasms / epidemiology, prevention & control* Prospective Studies Vegetables |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Department of Health; //Medical Research Council; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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