| Diet and age affect intestinal morphology and large bowel fermentative end-product concentrations in senior and young adult dogs. | |
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MedLine Citation:
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PMID: 16046720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine the effects of age and diet on intestinal morphology and large bowel fermentative end-product concentrations in healthy dogs. Small intestinal villus width, height, and area, and small intestinal and colonic crypt depth were measured. Large bowel digesta samples were analyzed for ammonia, SCFAs, and branched-chain fatty acids (BCFAs). SCFAs are considered to be beneficial fermentative end-products in the intestine because they exert trophic effects on intestinal cells. Twelve senior (age = 11.1 y +/- 0.6 at baseline; 6 male, 6 female) and 12 young adult (age = 8 wk old at baseline; 6 male, 6 female) beagles were randomly assigned to 1 of 2 dietary treatments, an animal product-based diet (APB) and a plant product-based diet (PPB). Diets were fed for 12 mo. Jejunal (P = 0.03) and ileal (P = 0.02) villus height, and duodenal (P = 0.04) villus width were greater for dogs consuming the PPB diet. Young dogs had greater (P = 0.04) jejunal villus height, whereas senior dogs had greater (P < 0.001) colonic crypt depth. Ammonia concentrations decreased (P = 0.03) from proximal to distal colon and were higher in dogs consuming APB (P = 0.03). Age and treatment affected butyrate concentrations, with senior dogs (P = 0.04) and dogs consuming APB (P = 0.04) having higher concentrations. Both diet and age affected small and large intestinal morphology, and colonic fermentative end-product concentrations in dogs. |
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Authors:
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Kristy N Kuzmuk; Kelly S Swanson; Kelly A Tappenden; Lawrence B Schook; George C Fahey |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 135 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-27 Completed Date: 2005-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1940-5 Citation Subset: IM |
Affiliation:
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Department of Animal Sciences, University of Illnois, Urbana, 61801, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animals Colon / growth & development, physiology* Diet* Digestion / physiology* Dogs / growth & development* Female Fermentation Male Models, Animal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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