Document Detail

Diet and Syndrome X.
MedLine Citation:
PMID:  11122785     Owner:  NLM     Status:  MEDLINE    
Syndrome X is a cluster of abnormalities, associated with resistance to insulin-mediated glucose uptake, that increases risk of coronary heart disease. Increased carbohydrate intake (with reciprocal decreased fat intake) within the boundaries of menus that can be followed in the free-living state have not been shown to decrease insulin resistance directly, by enhancing insulin sensitivity, or indirectly, by producing and maintaining weight loss. Moreover, such diets accentuate the metabolic abnormalities that constitute Syndrome X. Substitution of monounsaturated fat, polyunsaturated fat, or both for saturated fat results in the same reduction in low-density lipoprotein-cholesterol concentration as seen in diets low in fat and high in carbohydrates but without any untoward effects on the various manifestations of Syndrome X. Consequently, substituting unsaturated fat for saturated fat, without increasing intake of dietary protein or carbohydrate, may be useful for patients with hypercholesterolemia, Syndrome X, or both.
G M Reaven
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  2     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  IM    
Division of Cardiovascular Medicine, Falk CVRB, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA.
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MeSH Terms
Cholesterol, LDL / drug effects
Coronary Disease / diet therapy*
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Fatty Acids, Unsaturated / administration & dosage*,  therapeutic use
Hypercholesterolemia / diet therapy*
Insulin Resistance*
Weight Loss / physiology
Reg. No./Substance:
0/Cholesterol, LDL; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fatty Acids, Unsaturated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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