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Diepoxide-Triggered Conformational Transition of Silk Fibroin: Formation of Hydrogels.
MedLine Citation:
PMID:  22360530     Owner:  NLM     Status:  Publisher    
Silk fibroin hydrogels with tunable properties could be obtained from aqueous fibroin solutions (4.2 w/v %) in a short period of time. This was achieved by the addition of ethylene glycol diglycidyl ether (EGDE) into the reaction solution. Introduction of EGDE-cross-links between the fibroin molecules decreases the mobility of the chains, which triggers the conformational transition from random coil to β-sheet structure and hence, fibroin gelation. Dynamic rheological measurements conducted at 50oC show formation of strong to weak hydrogels depending on the pH of the reaction solution. Although EGDE attacks the amino groups of fibroin and forms interstrand cross-links, β-sheets acting as physical cross-links dominate the elasticity of the hydrogels. Mechanical response of low-modulus fibroin hydrogels formed above pH = 9.7 is highly nonlinear with strong strain hardening behavior (700 %) arising from the alignment of the crystallizable amino acid segments.
Ilknur Karakutuk; Fatih Ak; Oguz Okay
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-23
Journal Detail:
Title:  Biomacromolecules     Volume:  -     ISSN:  1526-4602     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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