| Diencephalic regions contributing to sympathetic nerve discharge in anesthetized cats. | |
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MedLine Citation:
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PMID: 3344835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reported that the forebrain is responsible for a significant component (38%) of inferior cardiac postganglionic sympathetic nerve discharge (SND) in baroreceptor-denervated cats anesthetized with alpha-chloralose [Huang et al., Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol. 21): R645-R652, 1987]. The current study was initiated to assess the contribution of various diencephalic regions to the forebrain-dependent component of SND in this preparation. For this purpose, the reductions in inferior cardiac SND and blood pressure produced acutely by midbrain transection at stereotaxic plane A3 in nonlesioned control cats were compared with those in cats in which diencephalic lesions were made with radio-frequency current. Lesions of the anterior medial hypothalamus including the paraventricular nucleus failed to attenuate the decreases in SND and blood pressure produced by midbrain transection. In contrast, the effects of midbrain transection were significantly attenuated by lesions of the lateral hypothalamus (including medial forebrain bundle), posterior medial hypothalamus, or the medial thalamus. We conclude that both the hypothalamus and medial thalamus contribute to SND in anesthetized cats. |
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Authors:
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Z S Huang; K J Varner; S M Barman; G L Gebber |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 254 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-03-30 Completed Date: 1988-03-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R249-56 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Blood Pressure Cats Chloralose Denervation Diencephalon / physiology* Electroencephalography Hypothalamus, Middle / physiology Paraventricular Hypothalamic Nucleus / physiology Pressoreceptors / physiology Sympathetic Nervous System / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-13187/HL/NHLBI NIH HHS; HL-33266/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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15879-93-3/Chloralose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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