Document Detail

Dielectrophoretic concentration of low-abundance nanoparticles using a nanostructured tip.
MedLine Citation:
PMID:  23137928     Owner:  NLM     Status:  Publisher    
Electric field-induced concentration has the potential for application in highly sensitive detection of nanoparticles (NPs) for disease diagnosis and drug discovery. Conventional two-dimensional planar electrodes, however, have shown limited sensitivity in NP concentration. In this paper, the dielectrophoretic (DEP) concentration of low-abundance NPs is studied using a nanostructured tip where a high electric field of 3 × 10(7) V m(-1) is generated. In experimental studies, individual 2, 10, and 100 nm Au NPs are concentrated to a nanotip using DEP concentration and are detected by scanning transmission and scanning electron microscopes. The DEP force on Au NPs near the end of a nanotip is computed according to the distance, and then compared with Brownian motion-induced force. The computational study shows qualitative agreement with the experimental results. When the experimental conditions for DEP concentration are optimized for 8 nm-long oligonucleotides, the sensitivity of a nanotip is 10 aM (10 attomolar; nine copies in a 1.5 μl sample volume). This DEP concentrator using a nanotip can be used for molecular detection without amplification.
Woon-Hong Yeo; Adrian M Kopacz; Jong-Hoon Kim; Xinqi Chen; Jinsong Wu; Dayong Gao; Kyong-Hoon Lee; Wing-Kam Liu; Jae-Hyun Chung
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-09
Journal Detail:
Title:  Nanotechnology     Volume:  23     ISSN:  1361-6528     ISO Abbreviation:  Nanotechnology     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241272     Medline TA:  Nanotechnology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  485707     Citation Subset:  -    
Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA.
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