| Dielectrophoresis of Caenorhabditis elegans. | |
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MedLine Citation:
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PMID: 21225036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We demonstrate for the first time the dielectrophoretic trapping and manipulation of a whole animal, the nematode Caenorhabditis elegans. We studied the effect of the electric field on the nematode as a function of field intensity and frequency. We identified a range of electric field intensities and frequencies that trap worms without apparent adverse effect on their viability. Worms tethered by dielectrophoresis (DEP) exhibit behavioral responses to blue light, indicating that at least some of the nervous system functions are unimpaired by the electrical field. DEP is useful to dynamically tether nematodes, sort nematodes according to size, and separate dead worms from live ones. |
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Authors:
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Han-Sheng Chuang; David M Raizen; Annesia Lamb; Nooreen Dabbish; Haim H Bau |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-11 |
Journal Detail:
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Title: Lab on a chip Volume: 11 ISSN: 1473-0189 ISO Abbreviation: Lab Chip Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-01 Completed Date: 2011-06-03 Revised Date: 2012-02-22 |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: England |
Other Details:
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Languages: eng Pagination: 599-604 Citation Subset: IM |
Affiliation:
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Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / radiation effects Caenorhabditis elegans / chemistry*, radiation effects Electromagnetic Fields Electrophoresis* Models, Theoretical |
| Grant Support | |
ID/Acronym/Agency:
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1R21HG004854-01A1/HG/NHGRI NIH HHS; NS064030/NS/NINDS NIH HHS; R01 NS064030-04/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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