| Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression. | |
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MedLine Citation:
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PMID: 20883140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the radioprotective effect of dieckol, a component of the brown algae Ecklonia cava. MATERIALS AND METHODS: Mice were lethally irradiated, treated with dieckol and surveyed for survival and the mechanism of radioprotection. RESULTS: Dieckol treatment lengthened the survival of irradiated mice and significantly accelerated the hemopoietic recovery of bone marrow cells and peripheral immune cells compared with irradiated, but untreated controls. Dieckol also enhanced the proliferation and differentiation of immune cells, which had been suppressed by ionising radiation. It turned out that the increased expression of oxygen radical-scavenging enzyme manganese superoxide dismutase (MnSOD) and subsequent reduction in DNA damage and lipid peroxidation was crucial for dieckol's radioprotective effect. In addition, the dieckol-induced modulation of protein 53 (p53)-dependent pathways further strengthened the radioresistance of immune cells. CONCLUSION: Dieckol can be a promising agent for reducing the time needed for reconstitution of hemopoietic cells after exposure to irradiation. |
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Authors:
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Eunjin Park; Ginnae Ahn; Jin-Suk Yun; Min Ju Kim; So Jin Bing; Dae Seung Kim; Jehee Lee; Nam Ho Lee; Jae Woo Park; Youngheun Jee |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of radiation biology Volume: 86 ISSN: 1362-3095 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: England |
Other Details:
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Languages: eng Pagination: 848-59 Citation Subset: IM; S |
Affiliation:
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Jeju National University, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Benzofurans / pharmacology* Cell Proliferation / drug effects DNA Damage Free Radical Scavengers / metabolism Gamma Rays Gene Expression Regulation, Enzymologic / drug effects Granulocyte-Macrophage Colony-Stimulating Factor / secretion Hematopoiesis / drug effects*, radiation effects Immune Tolerance / drug effects*, radiation effects Immunosuppression Kinetics Lipid Peroxidation / drug effects Mice Radiation-Protective Agents / pharmacology* Reactive Oxygen Species / metabolism Signal Transduction / drug effects Spleen / cytology, drug effects Survival Analysis Tumor Suppressor Protein p53 / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/Free Radical Scavengers; 0/Radiation-Protective Agents; 0/Reactive Oxygen Species; 0/Tumor Suppressor Protein p53; 0/dieckol; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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