| Did the first chordates organize without the organizer? | |
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MedLine Citation:
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PMID: 16023252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Models of vertebrate development frequently portray the organizer as acting on a largely unpatterned embryo to induce major components of the body plan, such as the neural plate and somites. Recent experiments examining the molecular and genetic basis of major inductive events of vertebrate embryogenesis force a re-examination of this view. These newer observations, along with a proposed revised fate map for the frog Xenopus laevis, suggest a possible reconciliation between the seemingly disparate mechanisms present in the ontogeny of the common chordate body plan of vertebrate and invertebrate chordates. Here, we review data from vertebrates and from an ascidian urochordate and propose that the organizer was not present at the base of the chordate lineage, but could have been a later innovation in the lineage leading to vertebrates, where its role was more permissive than instructive. |
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Authors:
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Matthew J Kourakis; William C Smith |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Trends in genetics : TIG Volume: 21 ISSN: 0168-9525 ISO Abbreviation: Trends Genet. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2005-11-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8507085 Medline TA: Trends Genet Country: England |
Other Details:
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Languages: eng Pagination: 506-10 Citation Subset: IM |
Affiliation:
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Molecular, Cell and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning / physiology Chordata* Chordata, Nonvertebrate / embryology Embryonic Development Evolution* Organizers, Embryonic / physiology* Xenopus laevis / embryology |
| Grant Support | |
ID/Acronym/Agency:
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HD041434/HD/NICHD NIH HHS; HD38701/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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