Document Detail

Dictyostelium discoideum: cellular self-organization in an excitable biological medium.
MedLine Citation:
PMID:  7740045     Owner:  NLM     Status:  MEDLINE    
The dynamics which govern the establishment of pattern and form in multicellular organisms remain a key problem of developmental biology. We study this question in the case of morphogenesis during aggregation of the slime mould Dictyostelium discoideum. Here detailed experimental information allows the formulation of a mechanistic model in which the central element is the coupling of the previously much-studied intracellular cyclic AMP signalling with the chemotactic cell response in cyclic AMP gradients. Numerical simulations of the model show quantitatively how signal relay, chemotactic movement and adaptation orchestrate the collective modes of cell signalling and migration in the aggregating cell layer. The interaction of chemotaxis with the cyclic AMP excitation waves causes the initially homogeneous cell layer to become unstable towards the formation of a branching cell stream pattern with close cell-cell contacts as observed in situ. The evolving cell morphology in turn leads to a pattern of non-homogeneous excitability of the medium and thus feeds back into the cAMP dynamics. This feedback can explain the decrease in signalling period and propagation speed with time, as well as observations on the structure of the spiral wave core in this self-organized excitable medium.
T Höfer; J A Sherratt; P K Maini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  259     ISSN:  0962-8452     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-06-07     Completed Date:  1995-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-57     Citation Subset:  IM    
Centre for Mathematical Biology, University of Oxford, U.K.
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MeSH Terms
Cell Adhesion / physiology
Chemotaxis / physiology
Culture Media
Cyclic AMP / metabolism
Dictyostelium / cytology*,  physiology
Models, Biological
Reg. No./Substance:
0/Culture Media; 60-92-4/Cyclic AMP

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