Document Detail


Dichlorodiphenyltrichloroethane (DDT), DDT metabolites and pregnancy outcomes.
MedLine Citation:
PMID:  23142753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Organochlorine pesticides (OCPs) are persistent endocrine disruptors. OCPs cross the placenta; this prenatal exposure has been associated with adverse pregnancy outcomes. We investigated associations between prenatal exposure to OCPs and gestational age and birth weight in 600 infants born between 1960 and 1963. The primary OCP was 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT), its primary metabolite, 1,1'-dichloro-2,2'-bis(p-chlorophenyl)ethylene (p,p'-DDE) and the contaminant, 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)-ethane (o,p'-DDT). Regression analysis indicated that for each natural log unit increase in p,p'-DDT, birth weight increased by 274 g (95% CI: 122, 425) when controlling for p,p'-DDE and o,p'-DDT. At a given level of p,p'-DDT exposure, o,p'-DDT and p,p'-DDE were associated with decreased birth weight. p,p'-DDE was negatively associated with length of gestation, controlling for p,p'-DDT and o,p'-DDT. These findings suggest opposing associations between exposure to p,p'-DDT and p,p'-DDE and birth weight. We did not find evidence to support mediation by maternal thyroid hormone status nor that the association differed by sex.
Authors:
Katrina L Kezios; Xinhua Liu; Piera M Cirillo; Barbara A Cohn; Olga I Kalantzi; Yunzhu Wang; Myrto X Petreas; June-Soo Park; Pam Factor-Litvak
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-09
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  35     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-17     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Birth Weight*
DDT / analogs & derivatives,  blood*
Dichlorodiphenyl Dichloroethylene / blood*
Endocrine Disruptors / blood*
Female
Gestational Age
Humans
Infant, Newborn
Male
Maternal Exposure / adverse effects*
Pregnancy / blood
Young Adult
Grant Support
ID/Acronym/Agency:
P30 ES009089/ES/NIEHS NIH HHS; P30ES009089/ES/NIEHS NIH HHS; R01 ES012460/ES/NIEHS NIH HHS; R01 ES017024/ES/NIEHS NIH HHS; R01ES012360/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Endocrine Disruptors; 4M7FS82U08/Dichlorodiphenyl Dichloroethylene; CIW5S16655/DDT
Comments/Corrections

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