| Dichlorodiphenyldichloroethylene exposure during the first trimester of pregnancy alters the anal position in male infants. | |
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MedLine Citation:
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PMID: 18991914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anogenital distance (AGD) at birth is regarded as a useful measurement that reflects the prenatal androgenic status in rodents. However, the impact of xenoantiandrogens on human development is largely unknown. The aim of this study was to evaluate the potential antiandrogenic impact of prenatal DDT metabolites (p,p'-DDE and p,p'-DDT) exposure on infant AGD, using a non-age-dependent anal position index (API). As part of an ongoing perinatal cohort study on the effects of organochlorine pesticides in children's neurodevelopment, we conducted a cross-sectional study in 71 infants (37 males and 34 females). Maternal serum levels of DDT metabolites (p,p'-DDE and p,p'-DDT) before and during each trimester of pregnancy were determined by electron capture gas-liquid chromatography. During postnatal home visits at 3, 6, and 12 or 18 months of age, the children's weight and API were evaluated. Multiple lineal regression models were used to estimate the potential endocrine disruptor activity of prenatal p,p'-DDE exposure. Boys had significantly higher API values than girls (0.6 versus 0.5; P < 0.001). Only among boys, a doubling increase of maternal p,p'-DDE serum levels during the first trimester of pregnancy, were associated with a significant reduction of API (beta=-0.02; P= 0.02). No effect of p,p'-DDT on AGD was observed. Evidence of the effect of prenatal p,p'-DDE on external genital differentiation is scarce and not consistent in the literature. Further studies are needed to confirm a hormonal disruptive effect on the development of external genitalia, due not only to p,p'-DDE but also due to other antiandrogenic persistent compounds. |
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Authors:
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Luisa Torres-Sanchez; Monica Zepeda; Mariano E Cebrián; Jaime Belkind-Gerson; Rosa M Garcia-Hernandez; Uri Belkind-Valdovinos; Lizbeth López-Carrillo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1140 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2008-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 155-62 Citation Subset: IM |
Affiliation:
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Instituto Nacional de Salud Publica, Morelos, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anal Canal
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abnormalities*,
drug effects Androgen Antagonists / metabolism Cohort Studies Dichlorodiphenyl Dichloroethylene / toxicity* Endocrine System / drug effects Female Humans Infant, Newborn Male Maternal Exposure* Mexico Pregnancy Pregnancy Trimester, First Regression Analysis Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists; 72-55-9/Dichlorodiphenyl Dichloroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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