Document Detail


Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism.
MedLine Citation:
PMID:  15070938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined acute and chronic effects of dichloroacetate (DCA) on maximal (MAX) and submaximal (SUB) exercise responses in patients with abnormal mitochondrial energetics. Subjects (n = 9) completed a MAX treadmill bout 1 h after ingesting 25 mg/kg DCA or placebo (PL). A 15-min SUB bout was completed the next day while receiving the same treatment. After a 1-d washout, MAX and SUB were repeated while receiving the alternate treatment (acute). Gas exchange and heart rate were measured throughout all tests. Blood lactate (Bla) was measured 0, 3, and 10 min after MAX, and 5, 10, and 15 min during SUB. MAX and SUB were repeated after 3 months of daily DCA or PL. After a 2-wk washout, a final MAX and SUB were completed after 3 months of alternate treatment (chronic). Average Bla during SUB was lower (P < 0.05) during both acute (1.99 +/- 1.10 vs. 2.49 +/- 1.52 mmol/liter) and chronic (1.71 +/- 1.37 vs. 2.39 +/- 1.32 mmol/liter) DCA vs. PL despite similar exercise intensities between conditions ( approximately 75 and 70% maximal exercise capacity during acute and chronic treatment). Thus, although DCA does not alter MAX responses, acute and chronic DCA attenuate the Bla response to moderate exercise in patients with abnormal mitochondrial energetics.
Authors:
G E Duncan; L A Perkins; D W Theriaque; R E Neiberger; P W Stacpoole
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-08     Completed Date:  2004-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1733-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Epidemiology, Nutritional Sciences Program, University of Washington, Seattle, Washington 98195, USA. duncag@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Child
Child, Preschool
Dichloroacetate / therapeutic use*
Energy Metabolism / drug effects*
Exercise*
Female
Humans
Lactic Acid / blood*
Male
Middle Aged
Mitochondria / metabolism*
Mitochondrial Diseases / drug therapy*,  metabolism*
Oxygen Consumption / drug effects
Grant Support
ID/Acronym/Agency:
ES-07355/ES/NIEHS NIH HHS; RR-00082/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
13425-80-4/Dichloroacetate; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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