Document Detail


Dichloroacetate attenuates myocardial acidosis and metabolic changes induced by partial occlusion of the coronary artery in dogs.
MedLine Citation:
PMID:  2095718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was undertaken to examine whether dichloroacetate, which inhibits pyruvate dehydrogenase kinase and, therefore, increases the activity of pyruvate dehydrogenase, attenuates myocardial acidosis and metabolic changes induced by coronary occlusion. In dogs anesthetized with pentobarbital, the left anterior descending coronary artery was incompletely occluded to reduce the left anterior descending flow to a half to one third of the original flow (partial occlusion) to produce myocardial (regional) ischemia. Partial occlusion was continued for 90 min, and a bolus injection of saline or dichloroacetate was made intravenously 30 min after the onset of occlusion. Partial occlusion decreased myocardial pH significantly. An injection of dichloroacetate (150 mg/kg) increased myocardial pH that had been lowered by partial occlusion. Myocardial metabolites were measured in other dogs. Partial occlusion decreased the myocardial levels of adenosine triphosphate, creatine phosphate and energy charge potential, and increased that of lactate significantly, without affecting the myocardial levels of pyruvate and nonesterified fatty acids. Dichloroacetate attenuated the ischemia-induced changes in the myocardial levels of adenosine triphosphate, creatine phosphate, energy charge potential and lactate. These results indicate that dichloroacetate attenuates the myocardial acidosis and metabolic changes during coronary partial occlusion.
Authors:
K Sakai; K Ichihara; Y Nasa; M Kamigaki; Y Abiko
Related Documents :
21738508 - A single intracoronary injection of midkine reduces ischemia/reperfusion injury in swin...
2568518 - Nipradilol, a beta-adrenoceptor antagonist having a vasodilatory action, attenuates myo...
7200778 - Effect of trapidil on regional myocardial function during acute coronary occlusion in t...
18325978 - Repeated inspiratory occlusions acutely impair myocardial function in rats.
12114858 - Practical use of t wave morphology assessment.
6711548 - Myocardial infarction among women in göteborg, sweden: a community study of mortality a...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  307     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-07-08     Completed Date:  1991-07-08     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  92-108     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Asahikawa Medical College, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acidosis / drug therapy*,  metabolism
Adenosine Triphosphate / metabolism
Animals
Coronary Disease / drug therapy,  metabolism*
Dichloroacetate / pharmacology*
Dogs
Energy Metabolism / drug effects
Fatty Acids, Nonesterified / metabolism
Female
Heart / drug effects*
Hydrogen-Ion Concentration
Lactates / metabolism
Lactic Acid
Male
Myocardium / metabolism*
Phosphocreatine / metabolism
Pyruvates / metabolism
Pyruvic Acid
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lactates; 0/Pyruvates; 127-17-3/Pyruvic Acid; 13425-80-4/Dichloroacetate; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inotropic effects of tanghinin and acetyl-tanghinin on guinea-pig isolated papillary muscle.
Next Document:  Lymphocytic myocarditis. Response to treatment with immunosuppressive drugs