Document Detail


Dicarbonyls stimulate cellular protection systems in primary rat hepatocytes and show anti-inflammatory properties.
MedLine Citation:
PMID:  18448803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Advanced glycation endproducts (AGEs) and their precursor dicarbonyls are generally perceived as having adverse health effects. They are also considered to be initiators and promoters of disease and aging. However, proof for a causal relationship is lacking. On the other hand, it is known that AGEs and melanoidins possess beneficial properties, such as antioxidant and metal-chelating activities. Furthermore, some AGEs may stimulate the cellular detoxification system, generally known as the phase II drug metabolizing system. We show here that several reactive dicarbonyl intermediates have the capability to stimulate the cellular phase II detoxification systems in both a reporter cell line and primary rat hepatocytes. In addition, we demonstrate that dicarbonyls can attenuate the inflammatory signaling induced by tumor necrosis factor-alpha in a reporter cell system.
Authors:
Timo M Buetler; Hélia Latado; Alexandra Baumeyer; Thierry Delatour
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1126     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-01     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Affiliation:
Nestlé Research Center, Lausanne 26, Switzerland. Timo.Buetler@rdls.nestle.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology*
Cell Line
Cells, Cultured
Gene Expression Regulation
Genes, Reporter
Glycosylation End Products, Advanced / pharmacology*
Hepatocytes / cytology,  drug effects,  physiology*
Hydroquinones / pharmacology*
Polymerase Chain Reaction
RNA / genetics
RNA, Messenger / genetics
Rats
TATA-Box Binding Protein / genetics
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glycosylation End Products, Advanced; 0/Hydroquinones; 0/RNA, Messenger; 0/TATA-Box Binding Protein; 1948-33-0/2-tert-butylhydroquinone; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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