Document Detail

Dibutyryl cAMP improves systemic vasoconstriction caused by endotoxin in dogs.
MedLine Citation:
PMID:  8721389     Owner:  NLM     Status:  MEDLINE    
We studied whether dibutyryl cyclic adenosine monophosphate (DbcAMP), which freely penetrates into the cells, improves systemic vasoconstriction caused by endotoxin in dogs. Thirteen anesthetized dogs were randomized into three groups. The endotoxin (ETX) group (n = 5) received only Escherichia coli endotoxin (3, intravenously). The ETX + DbcAMP group (n =5) received DbcAMP (6, intravenously) 30 min before the administration of endotoxin. The DbcAMP group received the same dose of DbcAMP 30 min after administration of saline. In the ETX group, systemic blood pressure and cardiac index significantly decreased, and systemic vascular resistance significantly increased, while in the ETX + DbcAMP group, increases in systemic and pulmonary vascular resistances after the administration of endotoxin were attenuated. DbcAMP did not cause hemodynamic changes in normal dogs. Plasma concentrations in thromboxane B2 in the ETX group were higher than in the ETX + DbcAMP group. Also, the change in plasma cyclic AMP concentrations showed a good logarithmic correlation with the change in plasma thromboxane B2 concentrations after the administration of endotoxin (r = .908, log (delta T x B2) = -.002* (delta cAMP) + 3.786). We conclude that DbcAMP improves systemic vasoconstriction caused by endotoxin in dogs. The beneficial mechanism of DbcAMP on systemic vasoconstriction after the administration of endotoxin may be partially due to inhibition of thromboxane B2.
T Yanase; K Enzan; H Mitsuhata; T Horiguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  5     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-11-07     Completed Date:  1996-11-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  284-8     Citation Subset:  IM    
Department of Anesthesiology, Tama-nanbu Hospital, Tokyo, Japan.
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MeSH Terms
Blood Pressure / drug effects
Bucladesine / pharmacology*
Cardiac Output / drug effects
Cyclic AMP / blood
Dose-Response Relationship, Drug
Escherichia coli Infections / drug therapy
Hemodynamics / drug effects
Lethal Dose 50
Lipopolysaccharides / toxicity
Shock, Septic / chemically induced,  drug therapy*,  prevention & control
Thromboxane B2 / blood
Time Factors
Vascular Resistance / drug effects
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Lipopolysaccharides; 362-74-3/Bucladesine; 54397-85-2/Thromboxane B2; 60-92-4/Cyclic AMP

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