| Dibromodulcitol, mitomycin C and vinblastine (DMV) chemotherapy in advanced breast cancer. | |
| | |
MedLine Citation:
|
PMID: 6540188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A combination of dibromodulcitol 500 mg orally, mitomycin C 10 mg i.v. and vinblastine 10 mg i.v. all given on day 1 and repeated every 4 weeks was given to 40 patients with advanced breast cancer. All but one had received previous endocrine therapy. The response rate (CR + PR) in 24 previously untreated patients was 66% and was 37% in 16 previously treated patients. The survival of responders was significantly longer than non-responders. Thirty-two per cent of patients experienced nausea and vomiting. There was little myelosuppression or thrombocytopenia on the day of starting a new course of therapy but the haemoglobin dropped by 2 g/dl in 32% of patients during therapy. Thus DMV is a relatively non-toxic active regimen for patients with advanced breast cancer. |
| | |
Authors:
|
A Howell; J M Morrison; V H Bramwell; R N Harland; I J Moneypenny |
Related Documents
:
|
21690448 - Minimally invasive esophagectomy provides equivalent oncologic outcomes to open esophag... 20498388 - Phase ii evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of ... 1834118 - Epirubicin in advanced endometrial adenocarcinoma: a phase ii study of the grupo gineco... 7008938 - Randomized clinical trial comparing two dose regimens of icrf-159 in refractory maligna... 23534348 - Risk factors for recurrence after curative resection of hepatitis c-related hepatocellu... 8604448 - Docetaxel (taxotere): an overview of first-line monotherapy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of cancer & clinical oncology Volume: 20 ISSN: 0277-5379 ISO Abbreviation: Eur J Cancer Clin Oncol Publication Date: 1984 Jul |
Date Detail:
|
Created Date: 1984-09-19 Completed Date: 1984-09-19 Revised Date: 2006-04-24 |
Medline Journal Info:
|
Nlm Unique ID: 8112045 Medline TA: Eur J Cancer Clin Oncol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 873-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antibiotics, Antineoplastic / administration & dosage, adverse effects Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use* Breast Neoplasms / drug therapy* Female Humans Middle Aged Mitolactol / administration & dosage, adverse effects, toxicity Mitomycin Mitomycins / administration & dosage, adverse effects, toxicity Vinblastine / administration & dosage, adverse effects, toxicity |
| Chemical | |
Reg. No./Substance:
|
0/Antibiotics, Antineoplastic; 0/DMV protocol; 0/Mitomycins; 10318-26-0/Mitolactol; 50-07-7/Mitomycin; 865-21-4/Vinblastine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes of proliferation kinetics after X-irradiation of a human malignant melanoma grown in nude mi...
Next Document: Bone scintigraphy in patients with operable breast cancer stages I and II. Final conclusion after fi...