Document Detail


Dibenzo[def,p]chrysene (DBC) suppresses antibody formation in spleen cells following oral exposures of mice.
MedLine Citation:
PMID:  23151208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dibenzo[def,p]chrysene (DBC) is a potent environmental carcinogen in rodents, fish, and human cells examined in culture. There are numerous similarities between the patterns of cytochrome P-450 (P450) activation of DBC and its covalent binding to DNA and proteins with another polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA). Our lab has previously shown that DMBA produces immunosuppression in rodents and human cell systems. Therefore, the purpose of these studies was to examine the immunotoxicity of DBC in a rodent model that was found to be sensitive to the immunosuppressive effects of DMBA. Data showed that DBC had similar potency to DMBA in producing suppression of a T-dependent antibody response (TDAR) and altered spleen cell subsets in a similar manner as DMBA when DMBA was given by gavage for 5 d in corn oil to mice at doses of 1-100 mg/kg total cumulative doses. T-cell-independent antigen (TNP-Ficoll) responses were quantitatively less sensitive to DBC suppression. It was also found that as with DMBA, DBC produced a persistent immunosuppression, which lasted for at least 4 wk following dosing with a novel pill method for self-administration of DBC. In conclusion, DBC appears to possess many of the same characteristics of DMBA in terms of its immunotoxicity.
Authors:
Fredine T Lauer; Mary K Walker; Scott W Burchiel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  76     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-01-17     Revised Date:  2014-08-19    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  16-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antibody Formation / drug effects*,  immunology
Benzopyrenes / administration & dosage,  toxicity*
Biological Markers
Carcinogens, Environmental / administration & dosage,  toxicity*
Dose-Response Relationship, Drug
Ficoll / analogs & derivatives,  immunology
Male
Membrane Proteins
Mice
Mice, Inbred C57BL
Spleen / cytology,  drug effects*,  immunology*
Trinitrobenzenes / immunology
Grant Support
ID/Acronym/Agency:
P30 CA118100/CA/NCI NIH HHS; R01 ES019968/ES/NIEHS NIH HHS; R01ES019968-01A1/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Benzopyrenes; 0/Biological Markers; 0/Carcinogens, Environmental; 0/Membrane Proteins; 0/TNP-ficoll; 0/Trinitrobenzenes; 191-30-0/dibenzo(a,l)pyrene; 25702-74-3/Ficoll
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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