Document Detail


Diazepam in acute myocardial infarction. Clinical effects and effects on catecholamines, free fatty acids, and cortisol.
MedLine Citation:
PMID:  973905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diazepam is a valuable drug in cases of acute myocardial infarction. The 10 mg intravenous loading dose and the subsequent 15 mg oral dose of diazepam administered three times daily produced safe, pleasant sedation, and reduced the need for analgesics. A much reduced excretion of catecholamines was recorded. It is presumed that diazepam causes a lower stress reaction, which is beneficial in diminishing the incidence of malignant arrhythmias and preventing the existing myocardial injury from spreading.
Authors:
M Melsom; P Andreassen; H Melsom; T Hansen; H Grendahl; L K Hillestad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  38     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  804-10     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aspartate Aminotransferases / blood
Catecholamines / urine*
Diazepam / adverse effects,  blood,  therapeutic use*
Dopamine / urine
Epinephrine / urine
Fatty Acids, Nonesterified / blood*
Humans
Hydrocortisone / blood*
Male
Middle Aged
Myocardial Infarction / blood,  drug therapy*,  urine
Norepinephrine / urine
Shock, Cardiogenic / prevention & control
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Fatty Acids, Nonesterified; 439-14-5/Diazepam; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; EC 2.6.1.1/Aspartate Aminotransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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