| Diazepam versus clobazam for intermittent prophylaxis of febrile seizures. | |
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MedLine Citation:
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PMID: 20890683 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effectiveness of intermittent clobazam versus diazepam therapy in preventing the recurrence of febrile seizures and assess adverse effects of each drug. METHODS: This prospective randomized controlled trial was performed on neurologically normal children aged from 6 months to 5 years with a history of simple febrile seizures and normal electroencephalogram without any evidence of acute central nervous system infection. The patients were randomly prescribed with oral clobazam (37 cases) or diazepam (35 cases) when they developed a febrile disease. They were advised to use the medications during the first 48 h of the onset of fever. All the patients were monitored regarding developing seizure and adverse effects of the drugs. All patients were followed for 12 months. RESULTS: Overall, 243 episodes of fever occurred during the period, including 116 episodes in the clobazam group and 127 episodes in the diazepam group. Recurrence of seizures occurred in 2 (1.7%) subjects in the clobazam group, and in 4(3.1%) cases in the diazepam group. (P value=0.474). Twenty cases (54%) in the diazepam group and 5 (14.2%) cases in the clobazam group developed drowsiness and sedation during the follow-up period (P value=0.0001). CONCLUSIONS: Intermittent clobazam therapy seems advantageous to diazepam due to similar efficacy but significantly lower adverse effects such as drowsiness and sedation. |
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Authors:
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Nahid Khosroshahi; Fatemeh Faramarzi; Payman Salamati; Seeid Mohammad Ogaghi Haghighi; Kamyar Kamrani |
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Publication Detail:
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Type: Journal Article Date: 2010-10-02 |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 78 ISSN: 0973-7693 ISO Abbreviation: Indian J Pediatr Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 38-40 Citation Subset: IM |
Affiliation:
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Division of neurology, Department of pediatrics, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Nahidkhosroshahi@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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