Document Detail

Diastolic ventricular interaction: from physiology to clinical practice.
MedLine Citation:
PMID:  16810172     Owner:  NLM     Status:  MEDLINE    
The ventricles share a common septum and, therefore, the filling of one influences the compliance of the other. This phenomenon is known as direct diastolic ventricular interaction. The interaction is noticeably increased when the force exerted by the surrounding pericardium is raised, which is termed pericardial constraint. In healthy individuals, pericardial constraint is minor in the resting state. When right ventricular volume-to-pressure ratio acutely increases, however, such as during exercise, massive pulmonary embolism, or right ventricular infarction, notable diastolic ventricular interaction occurs. In this setting, the measured left ventricular intracavitary diastolic pressure overestimates the true left ventricular filling pressure, because the effect of external forces must be subtracted. Although growth of the pericardium can be a feature of chronic cardiac enlargement, here we review the evidence of the importance of diastolic ventricular interaction in certain acute and chronic disease processes, including heart failure.
Lynne Williams; Michael Frenneaux
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Cardiovascular medicine     Volume:  3     ISSN:  1743-4297     ISO Abbreviation:  -     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-30     Completed Date:  2006-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101226507     Medline TA:  Nat Clin Pract Cardiovasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  368-76     Citation Subset:  IM    
Department of Cardiovascular Medicine, University of Birmingham, Birmingham, UK.
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MeSH Terms
Heart Failure / physiopathology*
Heart Ventricles / physiopathology*
Myocardial Contraction / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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