Document Detail

Diastolic sounds and murmurs associated with mitral valve prolapse.
MedLine Citation:
PMID:  7460241     Owner:  NLM     Status:  MEDLINE    
Although mitral valve prolapse is often associated with a systolic click or murmur, it is not widely appreciated that a sound or murmur may also occur in diastole. Nine patients with a systolic click or murmur and echocardiographic evidence of mitral prolapse had, in addition, a diastolic sound or an early diastolic murmur best heard at the apex or left sternal border. The sound, which was of high frequency and easily audible, followed A2 by 70-110 msec (mean 94 +/- 5 msec), and coincided with the point where the prolapsed posterior leaflet returned from the left atrium and recoapted with the anterior mitral leaflet. The diastolic sound occurred 40-60 msec (mean 53 +/- 4 msec) before the E point of the echocardiogram and O point of the apexcardiogram, and even longer before the rapid-filling wave. The diastolic murmur, also of high frequency, was brief and decrescendo, and simulated aortic regurgitation in two patients. Thus, mitral prolapse may be associated with a sound or murmur in diastole. When a diastolic sound or murmur is best heard apically, even if accompanied by a systolic murmur, mitral valve prolapse should be considered.
J Y Wei; N J Fortuin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  63     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-04-21     Completed Date:  1981-04-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  AIM; IM    
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MeSH Terms
Heart Auscultation*
Heart Murmurs*
Heart Sounds*
Middle Aged
Mitral Valve Prolapse / physiopathology*
Myocardial Contraction*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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