Document Detail


Diastolic myocardial dysfunction does not affect survival in patients with cirrhosis.
MedLine Citation:
PMID:  22909305     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Left ventricular diastolic dysfunction (DDF) has been considered as a component of cirrhotic cardiomyopathy. The clinical significance of DDF in cirrhotics has not been clarified. We prospectively evaluated the echocardiographic-Doppler, tissue-Doppler (TDI) findings of left ventricular function and survival in cirrhotics with or without DDF. Seventy-six cirrhotics without endogenous heart disease were included. DDF was diagnosed by mitral inflow Doppler parameters and diastolic myocardial velocities. Assessments of demographics, liver dysfunction, laboratory, echocardiographic systolic/diastolic indices, TDI of mitral annular motion and M-mode echocardiography were recorded. Patients were followed-up for a median of 25 months (15-40). DDF was diagnosed in 51 (67%) patients. Patients with compared with those without DDF had significantly older age and higher pulse rate as well as more frequently severe ascites, greater aortic root diameter and interventricular septal thickness. There was no difference in systolic myocardial function between two groups. Patients with DDF had a trend for worse survival (long rank, P = 0.094). A multivariate analysis showed that age, MELD and sodium but no DDF were predictive of death. DDF is prevalent in advanced cirrhosis and is associated with severe ascites. Systolic myocardial function and mortality do not seem to be strongly affected by the presence of DDF.
Authors:
Alexandra Alexopoulou; George Papatheodoridis; Sophia Pouriki; Christina Chrysohoou; Leonidas Raftopoulos; Christodoulos Stefanadis; Dimitrios Pectasides
Related Documents :
21963835 - Cardiac regeneration therapy: connections to cardiac physiology.
21772685 - Changes in myocardial lactate, pyruvate and lactate-pyruvate ratio during cardiopulmona...
8737855 - 1995: the year of the calcium antagonist controversy.
21638985 - Predictors of adverse outcome in a diabetic population following acute coronary syndromes.
17467915 - Small skin burn injury reduces cardiac tolerance to ischemia via a tumor necrosis facto...
18830415 - Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  -     ISSN:  1432-2277     ISO Abbreviation:  Transpl. Int.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Transplant International © 2012 European Society for Organ Transplantation.
Affiliation:
 2nd Department of Medicine, University of Athens Medical School, Hippokration General Hospital, Athens, Greece  First Cardiology Department, University of Athens Medical School, Hippokration General Hospital, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of proteins associated with the Pseudomonas aeruginosa biofilm extracellular matrix.
Next Document:  Prevalence of co-morbid depression in out-patients with type 2 diabetes mellitus in Bangladesh.