Document Detail

Diastolic indexes during dobutamine stress echocardiography in patients early after myocardial infarction.
MedLine Citation:
PMID:  9487467     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine whether Doppler parameters assessed during dobutamine stress echocardiography in the early phase after myocardial infarction could discriminate patients with residual ischemia from those without. Thirty-six patients after a recent myocardial infarction with and without residual ischemia underwent dobutamine stress echocardiography, adenosine sestamibi scintigraphy, and coronary angiography within 2 weeks after the acute event. The only diastolic Doppler parameter discriminating the two groups was the isovolumic relaxation time (IVRT) measured at the peak of the dobutamine infusion. It became shorter in both groups but significantly more in patients without than in those with residual ischemia despite a larger increase in heart rate in the latter group. IVRT at rest was 78 +/- 18 msec and decreased with high-dose dobutamine to 54 +/- 11 msec in the control group and to 69 +/- 16 msec in the ischemic group (p < 0.01). In addition, the rate-corrected IVRT (IVRTc) was calculated: IVRTc = IVRT/sqrtRR. The value of IVRTc = 80 at peak dobutamine infusion is able to discriminate patients with residual ischemia from those without with a sensitivity of 80% and a specificity of 70%.
A Dabrowska-Kugacka; M J Claeys; F E Rademakers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  11     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-35     Citation Subset:  IM    
Department of Cardiology, University Hospital of Antwerp, Edegem, Belgium.
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MeSH Terms
Adenosine / administration & dosage
Aged, 80 and over
Blood Pressure
Dobutamine / diagnostic use*
Echocardiography, Doppler*
Heart Catheterization
Heart Rate
Middle Aged
Myocardial Contraction
Myocardial Infarction / physiopathology,  radionuclide imaging,  ultrasonography*
Technetium Tc 99m Sestamibi / diagnostic use
Time Factors
Reg. No./Substance:
109581-73-9/Technetium Tc 99m Sestamibi; 34368-04-2/Dobutamine; 58-61-7/Adenosine

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