| Diastolic heart failure: mechanisms and controversies. | |
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MedLine Citation:
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PMID: 18542106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological and experimental studies have documented both the rising burden of diastolic heart failure (DHF) and several mechanisms that distinguish this disease from systolic heart failure (SHF). Controversies continue to surround the term 'DHF' as well as its existence as a pathophysiological entity distinct from SHF. Approximately half of all patients who present with heart failure have near-normal systolic function and predominately abnormal diastolic function. Recent reports counter the commonly held belief that survival of patients with DHF is better than that of patients with SHF. The challenges associated with managing the DHF phenotype arise from the heterogeneous etiologies of the condition that include aging, diabetes mellitus, hypertension and ischemia. Lack of diastolic distensibility in DHF has been attributed primarily to hypertrophy and fibrosis. Extracellular matrix and cytoskeletal components including matrix metalloproteinases, titin isoforms, and the quality and quantity of collagen are implicated in DHF development. Impaired active relaxation of the contractile apparatus also contributes to DHF. Novel therapeutic targets that address the pathophysiology of this disease are being actively explored, although as yet there are no proven therapies for DHF. New epidemiologic and mechanistic data regarding DHF highlight the urgency with which the scientific community must address this important public health problem. |
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Authors:
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Maral Ouzounian; Douglas S Lee; Peter P Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-06-10 |
Journal Detail:
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Title: Nature clinical practice. Cardiovascular medicine Volume: 5 ISSN: 1743-4300 ISO Abbreviation: - Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-26 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101226507 Medline TA: Nat Clin Pract Cardiovasc Med Country: England |
Other Details:
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Languages: eng Pagination: 375-86 Citation Subset: IM |
Affiliation:
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Institute of Circulatory and Respiratory Health, CIHR, NCSB 11-1266, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Diabetes Mellitus / epidemiology Diagnosis, Differential Heart Failure, Diastolic / diagnosis, epidemiology, metabolism*, physiopathology* Humans Hypertension / epidemiology Myocardial Ischemia / epidemiology Myocardium / metabolism*, pathology Stroke Volume |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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