| Diastolic function in several stages of chronic kidney disease in patients with autosomal dominant polycystic kidney disease: a tissue Doppler imaging study. | |
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MedLine Citation:
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PMID: 17575469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study evaluates the prevalence of diastolic dysfunction (DD) in several stages of chronic kidney disease (CKD) in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS: 107 ADPKD patients performed echocardiographic and Doppler studies and a tissue Doppler imaging (TDI) study. Patients were divided in three groups: group 1, 57 patients with CKD stage I, group 2, 37 patients in stages II and III, and group 3, 13 patients with CKD stages IV and V (not on dialysis). RESULTS: In transmitral Doppler, 1 patient in group 1 compared to 5 in group 2, and 4 in group 3 exhibited DD (p < 0.005); moreover, E/A ratio decreases progressively from group 1 to 3 (p < 0.0001). In TDI, DD was observed in 8 patients in group 1, 17 in group 2, and 8 in group 3 had DD (p < 0.001). Em velocity, the best TDI parameter for DD, correlated with age, renal function and blood pressure. When adjusted for age, increased left ventricular mass index and decreased renal function were independent risk factors of DD. CONCLUSIONS: DD occurred progressively as renal function deteriorates in patients with ADPKD and this effect is independently related to age and blood pressure. |
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Authors:
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Edgar A F de Almeida; Eduardo I de Oliveira; José António Lopes; Ana G Almeida; Mário G Lopes; M Martins Prata |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-06-15 |
Journal Detail:
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Title: Kidney & blood pressure research Volume: 30 ISSN: 1423-0143 ISO Abbreviation: Kidney Blood Press. Res. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610505 Medline TA: Kidney Blood Press Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 234-9 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Serviço de Nefrologia e Transplantação Renal, Hospital de Santa Maria, Lisboa, Portugal. edealmeida@mail.telepac.pt <edealmeida@mail.telepac.pt> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure / physiology* Diastole / physiology Echocardiography, Doppler / methods* Female Humans Kidney Failure, Chronic / physiopathology, radiography* Male Middle Aged Polycystic Kidney, Autosomal Dominant / physiopathology, radiography* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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