Document Detail

Diastolic function in patients undergoing coronary angioplasty: influence of degree of revascularization.
MedLine Citation:
PMID:  2345236     Owner:  NLM     Status:  MEDLINE    
To assess the early effects of successful coronary angioplasty on Doppler-derived left ventricular filling patterns and the significance of the extent of revascularization on these variables, 31 patients undergoing coronary angioplasty were examined within 24 h before and after the revascularization procedure. After angioplasty, the peak early to late velocity ratio increased from 0.89 +/- 0.2 to 1.05 +/- 0.3 (p less than 0.0001) and the one-third filling fraction increased from 42 +/- 10% to 48 +/- 10% (p less than 0.0001). The percent atrial contribution to filling decreased from 45 +/- 7% to 41 +/- 8% (p less than 0.01), and the pressure half-time and the isovolumetric relaxation time shortened from 55 +/- 15 to 43 +/- 13 ms (p less than 0.001) and from 100 +/- 14 to 82 +/- 17 ms (p less than 0.0001), respectively. When comparing patients with complete (n = 23) and incomplete (n = 8) revascularization, the same changes in the Doppler variables were observed. However, the mean rate of acceleration of early filling increased significantly after angioplasty only in those patients with complete revascularization. These data indicate that the left ventricular diastolic filling pattern is modified significantly as early as 24 h after successful coronary angioplasty. Improvement in impaired relaxation appears to be the most likely explanation for these changes, although increased myocardial stiffness in patients with incomplete revascularization is an alternative hypothesis.
R Castello; A C Pearson; M J Kern; A J Labovitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  15     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-03     Completed Date:  1990-07-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1564-9     Citation Subset:  AIM; IM    
Department of Internal Medicine, St. Louis University School of Medicine, Missouri.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Circulation
Coronary Disease / diagnosis,  physiopathology,  therapy*
Echocardiography, Doppler
Heart / physiopathology*
Middle Aged
Postoperative Period

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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