| Diastolic function and BNP changes during exercise predict oxygen consumption in chronic heart failure patients. | |
| | |
MedLine Citation:
|
PMID: 18609042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
B-type natriuretic peptide (BNP) is a diagnostic and prognostic marker in heart failure (CHF) patients. AIM: To assess the relation between BNP, diastolic function and exercise capacity in CHF patients. METHODS: Fifty CHF patients underwent cardiopulmonary exercise testing. BNP levels were determined at baseline and at peak exercise. Patients were divided in two groups: with lower (<14 ml/kg/min) or higher (>or=14 ml/kg/min) peak oxygen consumption (VO(2)). RESULTS: Seventeen patients with lower peak VO(2) showed larger incidence of restrictive pattern of the transmitral flow (7/17 vs 4/33, p =0.036). E/Ea ratio was inversely related with peak VO(2) (r =-0.419, p =0.004) and directly related with BNP levels at baseline (r =0.449, p =0.001) and at peak exercise (r =0.475, p =0.001). LV ejection fraction was similar in the two groups. Independent predictors of exercise tolerance were E/Ea ratio (p =0.003), lg BNP at baseline (p =0.034) and increase in lg BNP during exercise (p =0.038). CONCLUSIONS: In CHF patients, E/Ea ratio is a predictor of exercise tolerance and is related with BNP level at rest and at peak exercise. |
| | |
Authors:
|
Quirino Ciampi; Gabriele Borzillo; Emanuele Barbato; Bruno Petruzziello; Sandro Betocchi; Bruno Villari |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Scandinavian cardiovascular journal : SCJ Volume: 43 ISSN: 1651-2006 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-01-13 Completed Date: 2009-03-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: England |
Other Details:
|
Languages: eng Pagination: 17-23 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Fatebenefratelli Hospital, Benevento, Italy. qciampi@iol.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Biological Markers / blood Chronic Disease Echocardiography, Doppler, Color Echocardiography, Doppler, Pulsed Exercise Test* Exercise Tolerance* Female Heart Failure / diagnosis*, metabolism, physiopathology Humans Male Middle Aged Myocardial Contraction Natriuretic Peptide, Brain / blood* Oxygen Consumption* Predictive Value of Tests Prognosis Prospective Studies Stroke Volume Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The kinetics of lipid micro-emboli during cardiac surgery studied in a porcine model.
Next Document: Elevated glycosylated haemoglobin (HbA1c) is a risk marker in coronary artery bypass surgery.