Document Detail

Diastolic filling abnormalities in children with essential hypertension.
MedLine Citation:
PMID:  17452225     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate whether essential hypertension impacts diastolic function in children. STUDY DESIGN: In this cross-sectional study, patients with essential hypertension (n = 50) were compared with a normotensive group (n = 53). Echocardiographic assessment of diastolic function included measures derived from transmitral, color M-mode, and tissue Doppler interrogation. Cardiac dimensions, wall thickness, geometry, and systolic function were also assessed. Multiple linear regression analysis was performed to identify predictors of altered diastolic function. RESULTS: Diastolic filling abnormalities were found in 36% of the children with blood pressure elevation. Those subjects with concentric hypertrophy were more significantly affected. Abnormalities in indices reflective of left ventricular (LV) relaxation occurred more commonly (39%) than those of LV compliance (33%). Elevated indexed LV mass was found to be the most significant independent predictor of diastolic filling abnormalities. CONCLUSIONS: LV diastolic filling abnormalities were found in one-third of the pediatric subjects with essential hypertension. Whether these changes represent an adaptive or maladaptive response requires further study.
William L Border; Thomas R Kimball; Sandra A Witt; Betty J Glascock; Philip Khoury; Stephen R Daniels
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  150     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  503-9     Citation Subset:  AIM; IM    
Cardiovascular Imaging Core Research Laboratory, Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.
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MeSH Terms
Cross-Sectional Studies
Hypertension / physiopathology*

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