Document Detail


Diastolic filling abnormalities by color kinesis in newborns exposed to intrauterine cocaine.
MedLine Citation:
PMID:  12019428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because cocaine crosses the placenta, we prospectively evaluated global and segmental systolic and diastolic cardiac function by color kinesis in clinically asymptomatic newborns who were exposed to cocaine in utero (group 1, n = 82). Their data were compared with normal controls (group 3, n = 87) and newborns exposed to drugs other than cocaine (group 2, n = 108). During left ventricular filling, newborns exposed to cocaine, compared with groups 2 and 3, had significantly (P <.05) higher global fractional area change (%) (76 +/- 10.3 vs 72 +/- 9.4 and 72 +/- 9.1, respectively), regional fractional area changes (%) for the anterior, septal, inferior, and lateral wall, and in the index of asynchrony (at 50% filling 13.2 +/- 5.8 vs 11.3 +/- 4.1 and 11.6 +/- 4.2, respectively). There were no significant differences in systolic function among the 3 groups. Prenatal cocaine exposure in asymptomatic infants leads to higher global and segmental fractional area changes and asynchrony during diastole. The significance and course of these alterations require further investigation.
Authors:
Sudhir Ken Mehta; Dennis M Super; Ann Salvator; Lynn Singer; David Connuck; Linda Goetz Fradley; Rose A Harcar-Sevcik; James D Thomas; Jing Ping Sun
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  15     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-20     Completed Date:  2002-07-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-53     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA. Ken.mehta@fairviewhospital.org
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MeSH Terms
Descriptor/Qualifier:
Cocaine / toxicity*
Diastole / physiology
Echocardiography, Doppler, Color*
Female
Fetus / drug effects*
Heart Rate / drug effects
Humans
Infant, Newborn
Male
Pregnancy
Prospective Studies
Ventricular Function, Left / drug effects*
Grant Support
ID/Acronym/Agency:
M01RR00080/RR/NCRR NIH HHS; R01-DA09049/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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